Colchicine-Loaded Lipid Bilayer-Coated 50 nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization upon Cell Uptake
Colchicine-Loaded Lipid Bilayer-Coated 50 nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization upon Cell Uptake
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DOI：
10.1021/nl100991w
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发表时间：
2010-07-01
期刊：
影响因子：
10.8
通讯作者：
Bein, Thomas
中科院分区：
文献类型：
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作者：
Cauda, Valentina;Engelke, Hanna;Bein, Thomas
我们报告了一种一步组装路线，其中将支持的脂质双层（SLB）沉积在功能化胶体介孔二氧化硅（CMS）纳米颗粒上，形成核壳杂化系统（SLB@CMS）。支持的膜充当完整的屏障，防止封装的染料分子逃逸。这些负载有抗癌药物秋水仙碱的稳定的SLB@CMS颗粒很容易被细胞吸收，并导致微管解聚，与溶液中相同剂量的药物相比，效率显着提高
We report on a one-step assembly route where supported lipid bilayers (SLB) are deposited on functionalized colloidal mesoporous silica (CMS) nanoparticles, resulting in a core shell hybrid system (SLB@CMS) The supported membrane acts as an intact barrier against the escape of encapsulated dye molecules These stable SLB@CMS particles loaded with the anticancer drug colchicine are readily taken up by cells and lead to the depolymerization of microtubules with remarkably enhanced efficiency as compared to the same dose of drug in solution