Comparisons of percent equol producers between prostate cancer patients and controls: Case-controlled studies of isoflavones in Japanese, Korean and American residents
Comparisons of percent equol producers between prostate cancer patients and controls: Case-controlled studies of isoflavones in Japanese, Korean and American residents
复制标题
DOI：
10.1093/jjco/hyh015
复制
发表时间：
2004-02-01
影响因子：
2.4
通讯作者：
Pantuck, AJ
中科院分区：
文献类型：
--
作者：
Akaza, H;Miyanaga, N;Pantuck, AJ
背景：我们先前的病例对照研究显示，在日本的日本居民可以分为能够将大豆异黄酮大豆苷元降解成等量的人和那些没有这种能力的人，后者的前列腺癌发病率更高。方法：我们最近进行了一项类似的病例对照研究，不仅涉及在日本的日本居民，也包括在韩国的韩国居民。众所周知，韩国居民的前列腺癌发病率与日本居民的前列腺癌发病率接近。结果：日本295例(133例患者和162例对照)，韩国122例(61例患者和61例对照)，美国45例(24例患者和21例对照)。在日本(P=0.004)和韩国(P=0.001)，患者和对照组中产生马儿茶素的比例分别为29%和46%(P=0.004)和30%和59%。与日本和韩国人相比，美国人的活性异黄酮水平明显降低，产生马醇的比例也较低(患者为17%，对照组为14%)。结论：这些结果表明，产生马醇或马醇的能力本身与前列腺癌的低发病率密切相关。结果还表明，以大豆异黄酮为基础的饮食在预防前列腺癌方面将是有用的。
Background: Our previous case-control study revealed that the Japanese residents in Japan could be divided into those who are able to degrade daidzein, a soybean isoflavone, to equol and those without this ability, and that the incidence of prostate cancer is higher in the latter group.Methods: We recently conducted a similar case-control study involving not only Japanese residents in Japan but also Korean residents in Korea. The incidence of prostate cancer in Korean residents is known to be close to that of Japanese residents in Japan. On the other hand, American residents in the United States have a markedly higher incidence of prostate cancer as compared to Japanese residents in Japan.Results: The number of subjects was 295 in Japan (133 patients and 162 controls), 122 in Korea (61 patients and 61 controls) and 45 in the United States (24 patients and 21 controls). The percentage of equol producers among patients and controls was 29% and 46% in Japan (P = 0.004) and 30% and 59% in Korea (P = 0.001), respectively. The active isoflavone level was markedly lower and the percentage of equol producers was also lower (17% for patients and 14% for controls) for Americans as compared to the Japanese and Koreans.Conclusions: These results suggest that the ability of producing equol or equol itself is closely related to the lower incidence of prostate cancer. The results also suggest that a diet based on soybean isoflavones will be useful in preventing prostate cancer.