Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward.
Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward.
复制标题
DOI：
10.1097/yic.0000000000000412
复制
发表时间：
2022-11-01
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症过程与情绪障碍有关，但儿科患者的数据很少。本研究的目的是调查2010年至2015年因情绪障碍发作而入住青少年住院病房的青少年中中性粒细胞-淋巴细胞比率（NLR）升高（炎症标志物）与情绪极性（躁狂/抑郁）之间的可能相关性。对研究期间因心境障碍发作而入院的305例患者（年龄10-19岁，60.6%为男性）的电子病历进行了审查。其中，63人被诊断为躁狂发作，242人被诊断为抑郁发作。多变量分析用于比较两组之间和两组内的NLR，年龄、性别和抗精神病药物使用的协变。躁狂发作组的NLR显著高于抑郁组。此外，在多次住院的住院患者中，NLR在躁狂发作期间高于非躁狂状态。这些结果表明，正如在成人双相情感障碍中所报道的那样，炎症机制也可能参与青少年的情绪障碍，特别是在躁狂发作中。因此，临床医生可能会考虑添加抗炎药作为这些患者治疗的一部分。
Inflammatory processes are associated with mood disorders, but data on pediatric patients is scarce. The aim of this study was to investigate a possible association between elevated neutrophil - lymphocyte ratio (NLR) — a marker of inflammation, and mood polarity (manic/depressed), in adolescents, admitted between 2010-2015 due to a mood disorder episode, to an adolescent inpatient ward. Electronic medical records of 305 patients (aged 10-19 years, 60.6% males) admitted during the study period due to a mood disorder episode, were reviewed. Of these, 63 were diagnosed with manic episodes and 242 with depressive episodes. Multivariate analyses were used to compare NLR between and within the two groups, co-varying for age, sex, and antipsychotic use. NLR was significantly higher in the manic episode group compared to the depression one. Moreover, in inpatients with multiple hospitalizations, the NLR was higher during their manic episodes than during their non-manic states. These results suggest that, as has been reported in adults with bipolar disorder, inflammatory mechanisms may be involved in adolescents’ mood disorders as well, particularly in the manic episodes. Thus, clinicians may consider adding anti-inflammatories as part of the treatment of these patients.