High-resolution spectral domain anterior segment optical coherence tomography in type 1 Boston keratoprosthesis.
High-resolution spectral domain anterior segment optical coherence tomography in type 1 Boston keratoprosthesis.
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DOI：
10.1097/ico.0b013e318285c8f4
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发表时间：
2013-07
期刊：
影响因子：
2.8
通讯作者：
Mannis MJ
中科院分区：
文献类型：
--
作者：
Shapiro BL;Cortés DE;Chin EK;Li JY;Werner JS;Redenbo E;Mannis MJ
报告使用高分辨率傅立叶域眼前段光学相干断层扫描(AS-OCT)评估波士顿1型角膜假体(KPro)患者的成像结果。我们对植入波士顿KPro的患者进行了一项回顾性的对比研究。来自加州大学戴维斯眼科中心角膜服务部的23名患者的26只眼被纳入研究范围。受试者用海德堡工程公司的Spectralis AS-OCT进行评估。KPro手术的术前诊断包括角膜移植失败(69%)、化学烧伤(23%)和无虹膜(8%)。患者年龄17~88岁，平均63.2岁。54%的患者是女性。从KPro手术到获得高分辨率AS-OCT成像之间的平均时间为35.8个月(范围为2-90个月)。最常见的发现是假体后膜的形成，我们在77%的KPro眼中发现了这种情况。在65%的KPro眼中，我们发现了前板后面的上皮细胞，在54%的KPro眼中，我们发现了KPro前板前表面上的上皮唇。在31%的KPro眼中，我们发现了假体周围的囊、间隙或间隙，以及角膜载体移植物的变薄。傅立叶域AS-OCT对于KPro患者是一种有用的非侵入性成像技术，并提供了识别临床评估有时难以理解的变化的能力。较高分辨率的傅立叶域系统可能有助于临床诊断和处理可能无法用较低分辨率的仪器成像的病理。AS-OCT有可能监测植入的KPro的解剖稳定性，也可能有助于监测并发症。此外，高分辨率成像可能会增强我们对假体周围解剖的了解。
To report the results of imaging using high-resolution, Fourier domain anterior segment optical coherence tomography (AS-OCT) to evaluate patients with a type 1 Boston Keratoprosthesis (KPro). We performed a retrospective comparative study of patients in whom we implanted the Boston KPro. A total of 26 eyes of 23 patients from the Cornea Service at the University of California Davis Eye Center were included. Subjects were evaluated with the Spectralis AS-OCT (Heidelberg Engineering GmbH). Preoperative diagnoses for KPro surgery included failed corneal transplant (69%), chemical burn (23%), and aniridia (8%). The average age of patients was 63.2 years (range, 17–88 years). Fifty-four percent of the patients were female. The mean duration between the KPro surgery and the acquisition of high-resolution AS-OCT imaging was 35.8 months (range, 2–90 months). The most commonly observed finding was retroprosthetic membrane formation, which we found in 77% of KPro eyes. In 65% of KPro eyes, we identified epithelium behind the front plate, and in 54%, we identified an epithelial lip over the anterior surface of the KPro front plate. In 31% of KPro eyes, we identified periprosthetic cysts, gaps or spaces, and thinning in the corneal carrier graft. Fourier domain AS-OCT is a useful noninvasive imaging technique in patients with a KPro and provides the ability to identify changes that are sometimes difficult to appreciate by clinical evaluation. The higher resolution Fourier domain systems may aid in the clinical diagnosis and management of pathology that might not be imaged with instruments of lower resolution. AS-OCT has the potential for monitoring the anatomic stability of an implanted KPro and may also help to monitor for complications. Moreover, high-resolution imaging may enhance our understanding of periprosthetic anatomy.