Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women.
Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women.
复制标题
儿茶酚-O-甲基转移酶（COMT）基因多态性和年轻女性乳腺癌风险。
DOI：
10.1054/bjoc.2001.2009
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发表时间：
2001-09-14
影响因子：
8.8
通讯作者：
Wingren, S
中科院分区：
文献类型：
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作者：
Bergman-Jungestrom, M;Wingren, S
长期以来，雌激素暴露一直被认为是乳腺癌的主要危险因素。最近，人们的兴趣还集中在雌激素代谢物（例如儿茶酚雌激素）可能产生的致癌影响上。由儿茶酚-O-甲基转移酶 (COMT) 催化的 O-甲基化是使潜在致癌儿茶酚雌激素失活的一种途径。 COMT 蛋白的编码基因包含单核苷酸多态性 (SNP)，导致氨基酸移位 Val→Met，这已被证明可以决定酶的高活性和低活性构型。我们假设低活性等位基因 COMTMet 可能与早发性乳腺癌有关。在本病例对照研究中，包括 126 名年轻乳腺癌患者（≤ 36 岁）和 117 名健康女性献血者，我们分析了 COMTMet 基因型与乳腺癌风险之间的关联。病例和对照之间低/高活性等位基因的频率没有发现显着差异，表明多态性作为单一因素可能不会导致年轻女性乳腺癌的发生。 © 2001 癌症研究运动http://www.bjcancer.com
Oestrogen exposure has long been considered to be a main risk factor of breast cancer. More recently, interest has also focused on the possible carcinogenic influence from oestrogen metabolites, such as catechol oestrogens. O-methylation, catalysed by Catechol-O-Methyltransferase (COMT), is one pathway by which the potentially carcinogenic catechol oestrogens can be inactivated. The gene coding for COMT protein contains a single-nucleotide polymorphism (SNP), resulting in an amino acid shift Val→Met, which has been shown to determine high- and low-activity configuration of the enzyme. We hypothesized that the low-activity allele, COMTMet, may be implicated in early onset breast cancer. In the present case–control study, including 126 young breast cancer patients (≤ 36 years) and 117 healthy female blood donors, we analysed the association between COMTMet genotype and risk of breast cancer. No significant difference in the frequency of low-/high-activity alleles was found between cases and controls, indicating that the polymorphism, as a single factor, may not contribute to breast carcinogenesis in young women. © 2001 Cancer Research Campaignhttp://www.bjcancer.com