RENAL AFFERENT DENERVATION PREVENTS THE PROGRESSION OF RENAL-DISEASE IN THE RENAL ABLATION MODEL OF CHRONIC-RENAL-FAILURE IN THE RAT
RENAL AFFERENT DENERVATION PREVENTS THE PROGRESSION OF RENAL-DISEASE IN THE RENAL ABLATION MODEL OF CHRONIC-RENAL-FAILURE IN THE RAT
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DOI：
10.1016/0272-6386(95)90456-5
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发表时间：
1995-11-01
影响因子：
13.2
通讯作者：
KOSS, M
中科院分区：
文献类型：
--
作者：
CAMPESE, VM;KOGOSOV, E;KOSS, M
5/6肾切除大鼠发生高血压和肾功能进行性恶化，几种机制可能导致这些大鼠的高血压和进行性肾脏疾病，我们已经表明，交感神经系统活性增加可能导致慢性肾功能衰竭大鼠的高血压，然而，交感神经系统活性在肾脏疾病进展中的作用尚未研究，我们已经评估了神经源性因素是否有助于慢性肾功能衰竭大鼠肾消融模型中肾脏疾病的进展，Sprague-Dawley大鼠接受5/6肾切除术和背根切断术或假根切断术（CRF）。术后6周，慢性肾功能不全组大鼠的血压和血肌酐均低于假手术组。此外，5/6肾切除术和背根切断术的大鼠肾脏表现出比没有背根切断术的大鼠肾脏严重的肾小球硬化。这些研究表明，切除肾传入神经不仅可以预防高血压，还可以预防肾消融大鼠肾脏疾病的进展。虽然血压正常化肯定会发挥作用，但数据提高了肾脏神经原性冲动可能有助于肾脏疾病进展的可能性。(C)1995年由国家肾脏基金会，公司。
Rats with 5/6 nephrectomy develop hypertension and progressive deterioration in renal function, Several mechanisms may contribute to hypertension and to progressive renal disease in these rats, We have shown that increased activity of the sympathetic nervous system may contribute to hypertension in rats with chronic renal failure, However, the role of the sympathetic nervous system activity in the progression of renal disease has not been investigated, We have evaluated whether neurogenic factors contribute to the progression of renal disease in the renal ablation model of chronic renal failure in the rat, Sprague-Dawley rats underwent 5/6 nephrectomy and dorsal rhizotomy or sham rhizotomy (CRF). Age-matched normal rats were used as controls, Six weeks after surgery, rats with chronic renal failure and dorsal rhizotomy had lower blood pressure and serum creatinine than rats with sham rhizotomy. In addition, kidneys from rats with 5/6 nephrectomy and rhizotomy manifested less severe glomerulosclerosis than kidneys from rats without dorsal rhizotomy. These studies have demonstrated that resection of renal afferent nerves prevents not only hypertension, but also the progression of renal disease in rats with renal ablation, Although normalization of blood pressure may definitely play a role, the data raise the possibility that neurogenic impulses to the kidneys may contribute to the progression of renal disease. (C) 1995 by the National Kidney Foundation, Inc.