Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion.
Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion.
复制标题
DOI：
10.18632/oncotarget.16300
复制
发表时间：
2017-05-30
期刊：
影响因子：
--
通讯作者：
Giordano A
中科院分区：
文献类型：
--
作者：
Di Domenico M;Giordano A
Giulio Bizzozero根据组织在成年期的自我更新能力将其分为不稳定组织、稳定组织和永久组织。1940年，维克托·伯格尔和丽塔·列维·蒙塔尔奇尼揭示了利用一种特殊的配体神经生长因子（NGF）诱导永久性细胞生长的可能性。Stanley Cohen纯化了表皮生长因子（Epidermal Growth Factor， EGF）蛋白，该蛋白能够诱导表皮增生，引发早泄性眼睛和牙齿的出牙，建立了增殖和分化之间的“反比”关系。EGF诱导的这两种生物学效应是根据EGFR信号参与大量的细胞功能，如增殖、存活、粘附、迁移和分化。本文综述了生长因子信号及其下游效应物在肿瘤侵袭EMT过程中的关键作用，重点介绍了生长因子在肿瘤侵袭EMT过程中的调控作用。
Giulio Bizzozero classified the tissues concerning their capacity to self-renew during the adult life in labile, stable and permanent tissues. In 1940 Viktor Hamburger and Rita Levi Montalcini exposed the possibility to induce the growth of permanent cells thanks to a specific ligand Nerve Growth Factor (NGF). Stanley Cohen purified a protein the Epidermal Growth Factor (EGF), able to induce epidermis proliferation and to elicit precocious eye disclosure and teeth eruption, establishing the “inverse” relationships between the proliferation and differentiation. These two biological effects induced by EGF were according to EGFR signaling is involved in a large array of cellular functions such as proliferation, survival, adhesion, migration and differentiation. This review is focused on the key role of growth factors signaling and their downstream effectors in physiological and in pathological phenomena, the authors highlight the governance of Growth factors during the EMT in cancer invasion.