Antihapten antibodies in workers exposed to trimellitic anhydride fumes: a potential immunopathogenetic mechanism for the trimellitic anhydride pulmonary disease--anemia syndrome.
Antihapten antibodies in workers exposed to trimellitic anhydride fumes: a potential immunopathogenetic mechanism for the trimellitic anhydride pulmonary disease--anemia syndrome.
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接触偏苯三酸酐烟雾的工人中的抗半抗原抗体：偏苯三酸酐肺部疾病-贫血综合征的潜在免疫致病机制。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
C. Zeiss
中科院分区：
文献类型：
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作者：
Roy Patterson;Whitney W. Addington;Banner As;Byron Ge;M. Franco;Herbert Fa;Nicotra Mb;J. Pruzansky;Manuel Rivera;M. Roberts;David H. Yawn;C. Zeiss
吸入偏苯三酸酐(TMA)烟雾后出现的肺部疾病-贫血综合征包括咳嗽、咯血和呼吸困难伴肺浸润物、限制性呼吸缺陷、低氧血症和贫血。这种疾病可能是轻微的，中度的，或者可能是致命的。已经确认了一例可能的致命病例。尽管以前被认为是化学性肺炎，识别了另外两种免疫介导的TMA吸入性疾病，但TMA吸入性疾病促使对6名患有TMA肺部疾病-贫血综合征的工作人员和6名重病患者的同事进行了血清抗体分析。与以前在一家TMA生产厂吸入TMA粉末而被确认患有其他呼吸综合征的TMA工人的抗体浓度进行了比较。以Trimellityl人血清白蛋白和Trimellityl人红细胞为抗原。放射免疫分析法检测血清总抗体结合率及抗曲美利特人血清IgE和Ig G抗体浓度。
The pulmonary disease—anemia syndrome that occurs after inhalation of trimellitic anhydride (TMA) fumes consists of cough, hemoptysis and dyspnea with pulmonary infiltrates, a restrictive respiratory defect, hypoxemia, and anemia. The disease may be mild, moderate, or potentially fatal. A possible fatal case has been identified. Although previously considered a chemical pneumonitis, the recognition of 2 other types of immunologically mediated, TMA inhalational disease prompted the analysis of serum antibodies in 6 workers with TMA pulmonary disease—anemia syndrome and 6 co-workers of the most severely ill subject. A comparison was made with antibody concentrations of TMA workers previously identified as having other respiratory syndromes due to the inhalation of TMA powder in a TMA production plant. Trimellityl human serum albumin and trimellityl human erythrocytes were used as antigens. Radioimmunoassays examined total serum antibody binding and IgE and IgG antibody concentrations against trimellityl hum...