Highly sensitive fluorescent probes for zinc ion based on triazolyl-containing tetradentate coordination motifs
Highly sensitive fluorescent probes for zinc ion based on triazolyl-containing tetradentate coordination motifs
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DOI：
10.1021/ol702208y
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发表时间：
2007-11-22
期刊：
影响因子：
5.2
通讯作者：
Zhu, Lei
中科院分区：
文献类型：
--
作者：
Huang, Sha;Clark, Ronald J.;Zhu, Lei
两个新的含1，2，3-三唑基的N4-四齿配体在生理条件下对锌离子表现出纳摩尔亲和力。此外，它们可以很容易地衍生化成适合于灵敏的锌离子检测的荧光探针。固体和溶液结构表征表明，1，2，3-三唑基上的N_3和N_2分别与A和B中的锌离子配位，形成五元和六元配位环。该探针对锌离子表现出灵敏的荧光增强和比值响应。
Two new 1,2,3-triazolyl-containing N4-tetradentate ligands show nanomolar affinity for Zn2+ under physiological conditions. Furthermore, they are easily derivatizable to afford fluorescent probes suitable for sensitive Zn2+ detection. Structural characterizations in both solid and solution states suggest that N3 and N2 in the 1,2,3-triazolyl moiety coordinate with Zn2+ in A and B to afford five-membered and six-membered coordination rings, respectively. The probes show sensitive fluorescence enhancement and ratiometric responses to Zn2+.