Malondialdehyde, glutathione peroxidase and superoxide dismutase in peripheral blood erythrocytes of patients with acute cerebral ischemia
Malondialdehyde, glutathione peroxidase and superoxide dismutase in peripheral blood erythrocytes of patients with acute cerebral ischemia
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DOI：
10.1046/j.1468-1331.2001.00166.x
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发表时间：
2001-01-01
影响因子：
5.1
通讯作者：
Vural, O
中科院分区：
文献类型：
--
作者：
Demirkaya, S;Topcuoglu, MA;Vural, O
测量34名急性缺血性半球脑卒中患者在卒中发病后第1-7天红细胞（RBC）中丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Ps）和超氧化物歧化酶（SOD-1）的水平，并与性别、年龄和卒中危险因素匹配的30名对照个体进行比较。中风后24小时内，与对照组相比，患者的SOD和GSH-Px活性显着降低，MDA水平显着升高。 SOD 和 GSH-Px 活性的降低以及 MDA 水平的升高与 NIH 卒中量表评估的梗塞大小、初始卒中严重程度以及不良的短期预后显着相关。观察到的红细胞氧清除过程的变化在中风后 7 天内恢复到与对照受试者没有差异的值。我们的结果表明，在缺血性中风后的急性期，抗氧化酶浓度降低至正常水平以下。根据我们的结果，在抗氧化防御机制恢复之前（根据我们的结果，发生在中风发病后 7 天），使用神经保护疗法来对抗氧自由基损伤似乎是可靠的。
The levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Ps) and superoxide dismutase (SOD-1) were measured in the red blood cells (RBC) of 34 patients with acute ischemic hemispheric stroke on the first anti seventh day after their stroke onset, and compared with 30 control individuals matched for sex, age and stroke risk factors. Within the first 24 h after stroke, SOD and GSH-Px activities were significantly decreased and MDA levels were significantly elevated in the patients compared with control subjects. Decrease in SOD and GSH-Px activities and increase in MDA levels showed significant correlation with infarct sizer initial stroke severity assessed by NIH stroke scale and poor short-term prognosis. Observed changes in the RBC oxygen scavenging process returned to values not different from those of control subjects within seven days after stroke. Our results indicated that antioxidant enzyme concentrations decreased below normal levels in the acute period following ischemic stroke. Until the recovery of antioxidant defence mechanisms, which occurred up to seven days after stroke onset according to our results the use of neuroprotective therapy against oxyradical injury seems reliable.