A continuous linkage map of 22 short tandem repeat polymorphisms on human chromosome 12.
A continuous linkage map of 22 short tandem repeat polymorphisms on human chromosome 12.
复制标题
人类 12 号染色体上 22 个短串联重复多态性的连续连锁图。
作者：
Dawson,E;Shaikh,S;Weber,JL;Wang,Z;Weissenbach,J;Powell,JF;Gill,M
利用23个非ceph家系构建了人类12号染色体22个短串联重复多态性的连续连锁图谱。标记的平均分布距离为9.35 cM （3.1 ~ 33.9 cM）。其中18个标记可以被唯一定位，其概率为bbb1000:1。一些标记的物理位置表明，该图谱覆盖了85-95%的染色体。该框架图共有18个标记，雌性长213 cM，雄性长131 cM。除短臂远端部分外，女性重组频率高于男性重组频率。该图谱为先前在CEPH家系中建立的序列提供了确凿的证据，并独特地定位了4个额外的标记（CD4、ATPSB、D12S56、PLA2）。
A continuous linkage map consisting of 22 short tandem repeat polymorphisms has been constructed for human chromosome 12 using 23 non-CEPH pedigrees. The markers were distributed at an average distance of 9.35 cM (3.1-33.9 cM). Eighteen of the markers could be positioned uniquely with a likelihood of >1000:1. The physical locations of some of the markers suggest that the map covers 85-95% of the chromosome. This framework map of 18 markers has a female length of 213 cM and a male length of 131 cM. Female recombination frequencies were greater than male recombination frequencies except in the distal portion of the short arm. The map provides confirmatory evidence for orders established previously on CEPH pedigrees and uniquely positions 4 additional markers (CD4, ATPSB, D12S56, PLA2).