Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
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DOI：
10.1158/0008-5472.can-05-2553
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发表时间：
2005-10-15
期刊：
影响因子：
11.2
通讯作者：
van't Veer, LJ
中科院分区：
文献类型：
--
作者：
Weigelt, B;Hu, ZY;van't Veer, LJ
微阵列分析已被证明可以改善乳腺癌的风险分层。据报道，通过“内在”基因表达模式的分层聚类分析，乳腺肿瘤可细分为至少四种与不同患者结局相关的分子亚型。使用监督的方法，已经确定了70个基因的表达谱，预测年轻乳腺癌患者的临床转移的后期出现或不存在。在这里，我们表明，远处转移显示相同的分子乳腺癌亚型，以及70个基因的预后签名作为他们的原发性肿瘤。我们的研究结果表明，转移的能力是大多数乳腺癌的固有特征。此外，我们的数据表明，预后不良的乳腺癌分类的内在基因集或70个预后基因代表不同的疾病实体，似乎在整个转移过程中持续。
Microarray analysis has been shown to improve risk stratification of breast cancer. Breast tumors analyzed by hierarchical clustering of expression patterns of "intrinsic" genes have been reported to subdivide into at least four molecular subtypes that are associated with distinct patient outcomes. Using a supervised method, a 70-gene expression profile has been identified that predicts the later appearance or absence of clinical metastasis in young breast cancer patients. Here, we show that distant metastases display both the same molecular breast cancer subtype as well as the 70-gene prognosis signature as their primary tumors. Our results suggest that the capacity to metastasize is an inherent feature of most breast cancers. Furthermore, our data imply that poor prognosis breast carcinomas classified either by the intrinsic gene set or the 70 prognosis genes represent distinct disease entities that seem sustained throughout the metastatic process.