Enantioselective total synthesis of bistramide A
Enantioselective total synthesis of bistramide A
复制标题
DOI：
10.1021/ja057686l
复制
发表时间：
2006-04-19
影响因子：
15
通讯作者：
DeBaillie, AC
中科院分区：
文献类型：
--
作者：
Crimmins, MT;DeBaillie, AC
用最长的18步线性反应实现了双甲酰胺A的对映选择性合成。合成策略包括使用二立体选择性乙醇酸烷基化、N-酰基噻唑烷酮的氯钛烯醇化物的羟醛加成和Sharpless不对称环氧化来合成三个关键片段。
The enantioselective synthesis of bistramide A has been achieved with a longest linear sequence of 18 steps. The synthetic strategy involves the use of a distereoselective glycolate alkylation, an aldol addition of a chlorotitanium enolate ofN-acylthiazolidinthione, and a Sharpless asymmetric epoxidation to synthesize the three key fragments.