The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.
The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.
复制标题
唐氏综合征患者阿尔茨海默病和老年性痴呆的病理变化进展。
作者：
Burger Pc;F. Vogel
老年斑、神经细胞病变和颗粒空泡变性是阿尔茨海默病（早老性痴呆）和老年性痴呆的特征，也见于老年人的大脑。这些病变的发展进行了研究，在13例唐氏综合征，年龄12至65岁，定义的相似性和不同之处，如果有的话，在这四个条件下，他们的形态之间的目的。通过光学和电子显微镜（当应用时）进行评价，确定了表观鉴别。研究结果表明，唐氏综合征具有部分特征的基因型和表型异常，是研究这些病变发病机制的合适模型。
Senile plaques, neurofibrillary change and granulovacuolar degeneration characterize Alzheimer's disease (presenile dementia) and senile dementia and are also seen in the aged human brain. The development of these lesions was studied in 13 patients with Down's syndrome, ages 12 to 65, with the purpose of defining similarities and dissimilarities, if any, between their morphologies in these four conditions. Evaluation by light and, when applied, electron microscopy established apparent identities. The findings suggest that Down's syndrome, with its partially characterized genotypic and phenotypic abnormalities, is an appropriate model for the study of the pathogenesis of these lesions.