Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat
Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat
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DOI：
10.1111/j.1369-1600.2012.00468.x
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发表时间：
2013-07-01
影响因子：
3.4
通讯作者：
Ciccocioppo, Roberto
中科院分区：
文献类型：
--
作者：
de Guglielmo, Giordano;Cippitelli, Andrea;Ciccocioppo, Roberto
普瑞巴林（Lyrica）是γ-氨基丁酸（GABA）的结构类似物，并且被FDA批准用于部分性癫痫、神经性疼痛和广泛性焦虑症。普瑞巴林还降低兴奋性神经递质释放和突触后兴奋性。最近，我们证明普瑞巴林减少酒精摄入量，并防止复发酒精寻求引起的压力或环境刺激与酒精的可用性。在这里，我们试图通过检查普瑞巴林对可卡因自我给药（0.25 mg/输注）和由条件刺激和压力引起的可卡因寻求（如育亨宾给药（1.25 mg/kg））的影响来扩展这些发现。结果表明，口服普瑞巴林（0、10或30 mg/kg）可在较长时间（6小时）内减少可卡因的自我给药，但不会改变食物的自我给药。在可卡因恢复研究中，普瑞巴林（10和30 mg/kg）消除了由药理学应激物育亨宾和可卡因可用性预测线索引起的可卡因寻求。总体而言，这些结果表明，普瑞巴林可能在治疗可卡因成瘾的某些方面具有潜力。
Pregabalin (Lyrica) is a structural analog of -aminobutyric acid (GABA) and is approved by the FDA for partial epilepsy, neuropathic pain and generalized anxiety disorders. Pregabalin also reduces excitatory neurotransmitter release and post-synaptic excitability. Recently, we demonstrated that pregabalin reduced alcohol intake and prevented relapse to the alcohol seeking elicited by stress or environmental stimuli associated with alcohol availability. Here, we sought to extend these findings by examining the effect of pregabalin on cocaine self-administration (0.25mg/infusion) and on cocaine seeking elicited by both conditioned stimuli and stress, as generated by administration of yohimbine (1.25mg/kg). The results showed that oral administration of pregabalin (0, 10 or 30mg/kg) reduced self-administration of cocaine over an extended period (6 hours), whereas it did not modify self-administration of food. In cocaine reinstatement studies, pregabalin (10 and 30mg/kg) abolished the cocaine seeking elicited by both the pharmacological stressor yohimbine and the cues predictive of cocaine availability. Overall, these results demonstrate that pregabalin may have potential in the treatment of some aspects of cocaine addiction.