An instantaneous and highly selective chromofluorogenic chemodosimeter for fluoride anion detection in pure water.
An instantaneous and highly selective chromofluorogenic chemodosimeter for fluoride anion detection in pure water.
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DOI：
10.1002/open.201300010
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发表时间：
2013-04
期刊：
影响因子：
2.3
通讯作者：
Sancenon, Felix
中科院分区：
文献类型：
--
作者：
Elsayed, Sameh;Agostini, Alessandro;Santos-Figueroa, Luis E.;Martinez-Manez, Ramon;Sancenon, Felix
阴离子显色荧光传感器的开发是超分子化学领域中一个成熟的研究领域。[1]这是由于阴离子在生物过程、有害作用(如环境污染物)以及作为有毒化合物和致癌物种中的重要作用。[2]在无机阴离子中，氟被广泛用于预防龋齿和治疗骨质疏松症。[3]尽管有这些重要的应用，但急性暴露于这种阴离子可引起各种疾病，如恶心、腹痛、昏迷、低钙血症、骨骼氟中毒和骨软化。在过去的几年里，人们对开发用于选择性检测氟化物的显色荧光探针的兴趣与日俱增。[5]报道的大多数氟化物传感的例子都是基于“结合部位-信号亚单位”方法或“化学剂量计”方案的使用。[6]在使用结合部位-信号亚单位方法的探针中，一个光学信号单元共价键合到一个结合部位，该结合部位通常由一个或多个氢键供体部分组成，如尿素或硫脲基团。氟化物对结合部位的酸性质子的配位或去质子化引起颜色或荧光的变化，这使得阴离子检测成为可能。[7]尽管有这些重要的特征，根据这种范例构建的化学传感器存在一些缺点，例如缺乏选择性(其他碱性阴离子，如氰化物、乙酸盐和磷酸二氢，通常给出几乎相同的光学响应)，并且不能在竞争性介质中表现出传感特征，如水或混合水环境。
The development of chromofluorogenic sensors for anions is a well-established and studied field in the supramolecular chemistry realm.[1] This is due to the important roles of anions in biological processes, deleterious effects (such as environmental pollutants), and as toxic compounds and carcinogenic species.[2]Among inorganic anions, fluoride is widely used in the prevention of dental caries and in osteoporosis treatments.[3] In spite of these important applications, acute exposure to this anion can cause various diseases, such as nausea, abdominal pain, coma, hypocalcaemia, skeletal fluorosis and osteomalacia.[4] For all these reasons, the interest in developing chromofluorogenic probes for the selective detection of fluoride has grown in the last few years.[5] Most of the examples reported for fluoride sensing are based on the use of the “binding site–signalling subunit” approach or on the “chemodosimeter” protocol.[6] In the probes for which the binding site–signalling subunit approach is used, an optical signalling unit is covalently bonded to a binding site, which usually consists of one H-bond donor moiety or more, such as urea or thiourea groups. The coordination or deprotonation of the acidic protons of the binding sites by fluoride induces changes in colour or fluorescence, which enables anion detection.[7] In spite of these important features, the chemosensors constructed according to this paradigm present some drawbacks, such as lack of selectivity (other basic anions like cyanide, acetate and dihydrogenphosphate usually give nearly the same optical response) and are unable to display sensing features in competitive media such as water or mixed aqueous environments.
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影响因子：
2.1
作者：
Bhalla, Vandana;Tejpal, Ruchi;Kumar, Manoj
通讯作者：
Kumar, Manoj
影响因子：
3.6
作者：
HOFFMANN, KL;MAAS, G;REGITZ, M
通讯作者：
REGITZ, M
影响因子：
15
作者：
Yamaguchi, S;Akiyama, S;Tamao, K
通讯作者：
Tamao, K
影响因子：
5.2
作者：
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通讯作者：
Kim, Jong Seung
影响因子：
5.2
作者：
Bhalla, Vandana;Singh, Hardev;Kumar, Manoj
通讯作者：
Kumar, Manoj