C-reactive protein does not predict future depression onset in adolescents: preliminary findings from a longitudinal study.
C-reactive protein does not predict future depression onset in adolescents: preliminary findings from a longitudinal study.
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C 反应蛋白不能预测青少年未来抑郁症的发作：纵向研究的初步结果。
DOI：
10.1101/2023.10.26.23297634
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Gabbay,Vilma
中科院分区：
文献类型：
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作者：
Schwartz,JoshuaJ;Roske,Chloe;Liu,Qi;Tobe,RusselH;Ely,BenjaminA;Gabbay,Vilma
引言：神经炎症过程已被广泛牵连在许多神经精神疾病的基础神经生物学。C-反应蛋白（CRP）升高是临床实践中常用的非特异性炎症指标，与成人抑郁症相关。在青少年中，我们的研究小组先前发现CRP与神经奖励功能改变有关，但与横断面评估的情绪和焦虑症状无关。我们假设青少年与成人抑郁症中不同的CRP结果可能是由于慢性，随着时间的推移，神经炎症对精神疾病的影响逐渐积累。在这里，我们进行了一项纵向研究，以评估如果CRP水平预测未来的发病或进展的青少年depression in adolescent.Methods：参与者是53名青少年（年龄= 14.74 ± 1.92岁，35名女性），40精神症状和13名健康对照。在基线时，参与者完成半结构化诊断评估;焦虑，抑郁，快感缺乏和自杀严重程度的维度评估;以及血液检查以量化CRP水平。在1.5年后的纵向随访中重复进行临床评估。CRP水平与随访症状严重程度之间的斯皮尔曼相关性受体重指数、年龄、性别和随访间隔的控制，并在双尾Bonferroni调整后p < 0.05的水平上被认为是显著的。这可能表明CRP不是青少年抑郁和焦虑的有用生物标志物。然而，未来的纵向研究需要更大的样本量，并纳入其他指标的神经炎症。
Introduction:Neuroinflammatory processes have been extensively implicated in the underlying neurobiology of numerous neuropsychiatric disorders. Elevated C-reactive protein (CRP), an indicator of nonspecific inflammation commonly utilized in clinical practice, has been associated with depression in adults. In adolescents, our group previously found CRP to be associated with altered neural reward function but not with mood and anxiety symptoms assessed cross-sectionally. We hypothesized that the distinct CRP findings in adolescent versus adult depression may be due to chronicity, with neuroinflammatory effects on psychiatric disorders gradually accumulating over time. Here, we conducted a longitudinal study to evaluate if CRP levels predicted future onset or progression of depression in adolescents.Methods:Participants were 53 adolescents (age = 14.74 ± 1.92 years, 35 female), 40 with psychiatric symptoms and 13 healthy controls. At baseline, participants completed semistructured diagnostic evaluations; dimensional assessments for anxiety, depression, anhedonia, and suicidality severity; and bloodwork to quantify CRP levels. Clinical assessments were repeated at longitudinal follow-up after ∼1.5 years. Spearman's correlation between CRP levels and follow-up symptom severity were controlled for body mass index, age, sex, and follow-up interval and considered significant at the two-tailed, Bonferroni-adjustedp< 0.05 level.Results:After correction for multiple comparisons, no relationships were identified between baseline CRP levels and follow-up symptom severity.Conclusion:CRP levels were not significantly associated with future psychiatric symptoms in adolescents in this preliminary analysis. This may suggest that CRP is not a useful biomarker for adolescent depression and anxiety. However, future longitudinal studies with larger sample sizes and incorporating additional indicators of neuroinflammation are needed.