EFFECT OF HIBERNATION AND JEJUNAL BYPASS ON MUCOSAL STRUCTURE AND FUNCTION
EFFECT OF HIBERNATION AND JEJUNAL BYPASS ON MUCOSAL STRUCTURE AND FUNCTION
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DOI：
10.1152/ajpgi.1991.261.1.g37
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发表时间：
1991-07-01
影响因子：
--
通讯作者：
COOKE, HJ
中科院分区：
文献类型：
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作者：
CAREY, HV;COOKE, HJ
肠粘膜结构和功能可能受到与经口进食相关的全身因素以及粘膜与食物接触引发的局部反应的调节。 这项研究比较了这些因素在季节性长期禁食的动物模型中的相对影响。 空肠旁路手术或假手术进行了积极喂养地松鼠或松鼠，随后停止喂养和冬眠。 粘液湿重，蛋白质含量，绒毛高度，和表面积减少空肠段，有最小的暴露于管腔内容物（绕过段的活跃松鼠和冬眠动物的所有部分）相比，段暴露于管腔流（不连续性和假段的活跃松鼠）。 当标准化为粘膜重量，3-O-甲基葡萄糖和丙氨酸依赖性钠通量的跨上皮吸收更大的空肠段与最小的暴露于管腔营养。 尽管两组中存在不同的全身因素，但活动和冬眠松鼠绕过的部分的结构改变与功能参数的变化平行。 因此，在该动物模型中，粘膜与食物的接触，而不是与经口进食相关的全身因素，是维持粘膜质量的主要因素。 粘膜与营养物质接触的缺乏通过尚未确定的机制增强了特定的吸收功能。
Intestinal mucosal structure and function may be regulated by systemic factors associated with oral feeding, as well as local responses initiated by contact of the mucosa with food. This study compared the relative effects of these factors in an animal model that undergoes seasonal long-term fasting. Jejunal bypass operations or sham surgeries were performed on active fed ground squirrels or on squirrels that subsequently ceased feeding and hibernated. Mucosal wet weight, protein content, villus height, and surface area were reduced in jejunal segments that had minimal exposure to luminal contents (bypassed segments of active squirrels and all segments of hibernators) compared with segments exposed to the luminal stream (incontinuity and sham segments of active squirrels). When normalized to mucosal weight, transepithelial absorption of 3-O-methylglucose and alanine-dependent sodium flux were greater in jejunal segments with minimal exposure to luminal nutrients. Altered structure in bypassed segments of active and hibernating squirrels paralleled changes in functional parameters despite the presence of different systemic factors in the two groups. Thus, in this animal model, contact of the mucosa with food, and not systemic factors associated with oral feeding, is the primary factor maintaining mucosal mass. The absence of mucosal contact with nutrients enhances specific absorptive function by mechanisms that have yet to be determined.