The effect of repeated combined treatment with nifedipine and antidepressant drugs or electroconvulsive shock on the hippocampal corticosteroid receptors in rats
The effect of repeated combined treatment with nifedipine and antidepressant drugs or electroconvulsive shock on the hippocampal corticosteroid receptors in rats
复制标题
硝苯地平与抗抑郁药物重复联合治疗或电休克对大鼠海马皮质类固醇受体的影响
DOI：
10.1016/0028-3908(93)90036-3
复制
发表时间：
1993
影响因子：
4.7
通讯作者：
L. Jaworska
中科院分区：
文献类型：
--
作者：
E. Przegaliński;B. Budziszewska;J. Siwanowicz;L. Jaworska
本文观察了钙通道拮抗剂硝苯地平对长期抗抑郁药丙咪嗪和阿米替林或电休克（ECS）所致大鼠海马糖皮质激素（GR）和/或盐皮质激素受体（MR）密度变化的影响。长期丙咪嗪或阿米替林治疗显着增加GR的密度，而慢性ECS显着增加GR和MR的密度。硝苯地平重复给药的基础GR和MR水平没有影响，但当大鼠预先与硝苯地平，抗抑郁药和ECS不能增加GR的密度，或GR和MR，分别。这些结果表明，与其他模型不同，硝苯地平阻断了抗抑郁药和ECS对GR和/或MR的影响。它们还表明，抗抑郁药和ECS对GR和MR密度的影响不同。
The effect of nifedipine, a calcium channel antagonist, on changes in the density of glucocorticoid (GR) and/or mineralocorticoid receptors (MR), induced by long-term treatment with antidepressant drugs (imipramine and amitriptyline) or electroconvulsive shock (ECS) was investigated in the rat hippocampus. Long-term treatment with imipramine or amitriptyline significantly increased the density of GR, while chronic ECS significantly elevated the density of both GR and MR. Nifedipine administered repeatedly had no effect on the basal GR and MR levels, however when the rats were pretreated with nifedipine, the antidepressant drugs and ECS were unable to increase the density of GR, or GR and MR, respectively. These results indicate that, unlike in other models, nifedipine blocks the effects of antidepressant drugs and ECS on GR and/or MR. They also show, that antidepressant drugs and ECS differ in their effect on the density of GR and MR.
地塞米松抑制试验在抑郁症抗抑郁治疗中的应用。
影响因子：
--
作者：
Greden,JF;Gardner,R;King,D;Grunhaus,L;Carroll,BJ;Kronfol,Z
通讯作者：
Kronfol,Z