Training effects in mice after long-term voluntary exercise
Training effects in mice after long-term voluntary exercise
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DOI：
10.1249/01.mss.0000183179.86594.4f
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发表时间：
2006-02-01
期刊：
影响因子：
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通讯作者：
Hoffman-Goetz, L
中科院分区：
文献类型：
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作者：
Davidson, SR;Burnett, M;Hoffman-Goetz, L
背景：小鼠是运动研究免疫系统、癌症和衰老的重要动物模型。关于长期自愿运动对这一物种的训练效果的研究有限。目的：观察长期有氧运动对小鼠的训练效果。方法：雌性C57BL/6小鼠随机分为两组：1)有24 h进出的笼内跑轮的单笼（WR, N = 31）； 2)无跑轮的单笼（NR, N = 20），持续16周。对比目鱼、跖骨、红腓肠肌和白腓肠肌中的柠檬酸合成酶（CS）、丁二酸脱氢酶（SDH）和磷酸果糖激酶（PFK）活性进行了评估。结果：不同训练条件下，最终体质量和速度无显著差异。与NR小鼠相比，WR小鼠的RTE次数显著延长（P < 0.001）， VO2peak显著升高（P < 0.05）。与NR小鼠相比，WR小鼠比目鱼的CS和SDH活性更高（P < 0.01）。腓肠肌红（P < 0.01）。和跖肌（P < 0.01）。白色腓肠肌中，WR小鼠PFK活性高于NR小鼠（P < 0.01）。结论：雌性C57BL/6小鼠自愿跑轮活动16周后，跑到精疲力竭的时间更长。更高的vo2峰，以及更高的SDH和CS活性。这些研究结果表明，雌性C57BL/6小鼠的滚轮跑步：1)产生可测量的有氧训练效果；2)是长期训练研究的有效运动方式。
Background: Mice are an important animal model in exercise studies on the immune system, cancer, and aging. There is limited research about the training effects of long-term voluntary exercise in this species. Purpose: To describe the training effects in mice given long-term aerobic voluntary exercise. Methods: Female C57BL/6 mice were randomly assigned to 1) individual cages with in-cage running wheels with 24-h access (WR; N = 31), or 2) individual cages without running wheels for 16 wk (NR; N = 20). Run-to-exhaustion (RTE) times, VO2peak, speed at VO2peak, and citrate synthase (CS), succinate dehydrogenase (SDH), and phosphofructokinase (PFK) activity in the soleus, plantaris, and red and white gastrocnemius were assessed. Results: Final body weight and speed at VO2peak did not differ by training condition. WR mice had significantly longer RTE times (P < 0.001) and higher VO2peak (P < 0.05) compared with NR mice. Higher CS and SDH activities were found in WR compared with NR mice for soleus (P < 0.01). red gastrocnemius (P < 0.01). and plantaris (P < 0.01) muscles. PFK activity was higher in WR mice in white gastrocnemius compared with NR mice (P < 0.01). Conclusions: Voluntary running wheel activity for 16 wk in female C57BL/6 mice resulted in longer run times to exhaustion. higher VO2peak, and higher SDH and CS activities in oxidative muscles. These findings suggest that wheel running in female C57BL/6 mice: 1) produces a measurable aerobic training effect and 2) is an effective exercise modality for long-term training studies.