Molecular Cancer Smac/diablo Enhances the Therapeutic Potential of Chemotherapeutic Drugs and Irradiation, and Sensitizes Trail-resistant Breast Cancer Cells
Molecular Cancer Smac/diablo Enhances the Therapeutic Potential of Chemotherapeutic Drugs and Irradiation, and Sensitizes Trail-resistant Breast Cancer Cells
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发表时间：
2008
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通讯作者：
T. Fandy;S. Shankar;R. K Srivastava
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作者：
T. Fandy;S. Shankar;R. K Srivastava
背景：耐药性是癌症治疗中的一个主要问题。在这里，我们调查的临床潜力的第二个来源于caspase的激活剂（Smac/DIABLO）在提高乳腺癌中常用的抗癌药物（紫杉醇，阿霉素，依托泊苷，他莫昔芬），放射和TRAIL的诱导肿瘤坏死的潜力。
Background: Drug resistance is a major concern in cancer therapy. Here, we investigate the clinical potential of the second mitochondria-derived activator of caspase (Smac/DIABLO) in enhancing the apoptosis-inducing potential of commonly used anticancer drugs (paclitaxel, doxorubicin, etoposide, tamoxifen), irradiation and TRAIL in breast carcinoma.