Analysis of unsupported gait in toddlers with autism
Analysis of unsupported gait in toddlers with autism
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DOI：
10.1016/j.braindev.2010.07.006
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发表时间：
2011-05-01
影响因子：
1.7
通讯作者：
Muratori, Filippo
中科院分区：
文献类型：
--
作者：
Esposito, Gianluca;Venuti, Paola;Muratori, Filippo
目的：许多研究表明运动发育在自闭症中的重要性。运动发育被认为是自闭症的一个可能的生物标志，因为它不依赖于社会或语言的发展。在这项研究中，使用回溯性视频分析，我们调查了患有自闭症的蹒跚学步儿童的第一个无支撑步态。方法：将55名幼儿分为3组：自闭症组(AD，n=20，年龄14.2mo，SD=1.4mo)，正常发育组(TD，n=20，年龄12.9mo，SD=1.1mo)和非自闭症混合性病因发育迟缓儿童(DD，n=15，年龄13.1mo，SD=0.8mo)。使用步行观察量表(WOS)和步行中对称性位置模式(PPSW)收集第一次无支撑步态的数据。WOS包括11个项目，通过三个轴分析步态：脚部动作、手臂动作和一般动作，而PPSW则分析步态过程中的静态和动态对称性。结果：我们的研究结果表明，与对照组相比，AD组幼儿的步态模式存在显著差异。AD组与两个对照组的WOS(P<；.001)和PPSW(P<；.001)均有显著差异。结论：我们在自闭症中发现的运动障碍的特异性(姿势不对称)与先前的研究结果一致，即自闭症的运动症状与小脑受累有关。(C)2010年日本儿童神经病学学会。爱思唯尔出版，版权所有。
Aims: A number of studies have suggested the importance of motor development in autism. Motor development has been considered a possible bio-marker of autism since it does not depend on either social or linguistic development. In this study, using retrospective video analysis we investigated the first unsupported gait in toddlers with autism. Methods: Fifty-five toddlers, belonging to three groups were recruited: toddlers with autistic disorder (AD, n = 20, age 14.2 mo, sd 1.4 mo) and as comparison groups: typically developing toddlers (TD, n = 20, age 12.9 mo, sd 1.1 mo) and toddlers with non-autistic developmental delays of mixed aetiology (DD, n = 15, age 13.1 mo, sd 0.8 mo). The Walking Observation Scale (WOS) and the Positional Pattern for Symmetry during Walking (PPSW) were used to gather data on the first unsupported gait. The WOS includes 11 items that analyze gait through three axes: foot movements; arm movements; general movements while the PPSW analyses static and dynamical symmetry during gait. Results: Our results have identified significant differences in gait patterns among the group of toddlers with AD as opposed to the control groups. Significant differences between AD and the two control groups were found for both WOS (p < .001) and PPSW (p < .001). Conclusion: The specificity of motor disturbances we have identified in autism (postural asymmetry) is consistent with previous findings that implicated cerebellar involvement in the motor symptoms of autism. (C) 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.