Resting energy expenditure in chronic hepatitis C
Resting energy expenditure in chronic hepatitis C
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DOI：
10.1034/j.1600-0641.2000.033004623.x
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发表时间：
2000-10-01
影响因子：
25.7
通讯作者：
Hébuterne, X
中科院分区：
文献类型：
--
作者：
Piche, T;Schneider, SM;Hébuterne, X
Background/Aims: Hypermetabolism is considered to be of clinical interest in liver disease and in several chronic viral infections. Whether resting energy expenditure (REE) increases during chronic hepatitis C is not known. Our aims, were: (a) to determine the metabolic state of patients with chronic hepatitis C, and (b) to evaluate the effects of interferon therapy on REE.Methods: Forty-seven patients and 20 controls were studied. Sixteen patients failed to respond to interferon and 12 patients stopped the treatment during the first 2 months for various reasons. The 19 responders all received 1 year of interferon, REE (indirect calorimetry) and fat-free mass (FFM, bioelectric impedance analysis) were evaluated before (day 0) and after 90, 180, and 360 days of interferon. The virus load was evaluated in patients before treatment.Results: On day 0, REE expressed as a ratio of FFM (REE/FFM) was higher in patients than in controls (129.2+/-14.7 vs 117.9+/-9.6 kJ kgFFM(-1) 24 h(-1), p
