Transient increase of retinal nerve fiber layer thickness after macular hole surgery
Transient increase of retinal nerve fiber layer thickness after macular hole surgery
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DOI：
10.1007/s10792-013-9855-y
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发表时间：
2014-06-01
影响因子：
1.6
通讯作者：
Terasaki, Hiroko
中科院分区：
文献类型：
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作者：
Hibi, Nobuaki;Kondo, Mineo;Terasaki, Hiroko
我们使用光谱域光学相干断层扫描（SD-OCT）研究了特发性黄斑裂孔（MH）手术后视网膜神经纤维层（RNFL）厚度的变化。研究了20例连续患者的20只眼，这些患者接受了玻璃体切除术以闭合MH。在术前和术后1、3、6个月，通过SD-OCT测量视乳头周围RNFL厚度。分析RNFL的平均总厚度、四个象限的厚度以及12个时钟小时中每个时钟小时的厚度。术前平均RNFL厚度为93.3 ± A9.6 μ m，术后1个月显著增加至98.7 ± A7.4 μ m（P < 0.05）。平均总厚度在3个月和6个月时恢复到术前水平。术后1个月，RNFL厚度在上级、鼻侧和下象限的一过性增加具有统计学显著性。鼻象限厚度的增加保持长达6个月。当分析个体12点钟的厚度时，在手术后1个月，0-5点钟位置的每个位置的RNFL厚度的瞬时增加是显著的。MH手术后RNFL厚度的短暂增加可能是由MH手术引起的视网膜内层轻度水肿引起的。
We studied the changes in the thickness of the retinal nerve fiber layer (RNFL) after surgery for idiopathic macular hole (MH) using spectral-domain optical coherence tomography (SD-OCT). Twenty eyes of 20 consecutive patients who underwent vitrectomy to close a MH were studied. The peripapillary RNFL thickness was measured by SD-OCT before and at 1, 3, and 6 months after surgery. The mean overall thickness, the thickness of the four quadrants, and the thickness of each of the 12 clock hours of the RNFL were analyzed. The mean overall RNFL thickness before surgery was 93.3 +/- A 9.6 mu m, and it increased significantly to 98.7 +/- A 7.4 mu m at 1 month after surgery (P < 0.05). The mean overall thickness then returned to the pre-surgery level at three and 6 months. The transient increase of RNFL thickness at 1 month after surgery was statistically significant in the superior, nasal, and inferior quadrants. The increase in the thickness of the nasal quadrants was maintained for up to 6 months. When the thickness of the individual 12 clock hours were analyzed, the transient increase of RNFL thickness at 1 month after surgery was significant at each of the 0-5 o'clock positions. The transient increase in the RNFL thickness after MH surgery may be caused by mild edema of the inner retinal layers caused by the MH surgery.