Signaling molecules and pathways regulating the fate of spermatogonial stem cells.
Signaling molecules and pathways regulating the fate of spermatogonial stem cells.
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信号分子和途径调节精子干细胞的命运。
DOI：
10.1002/jemt.20698
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发表时间：
2009-08
影响因子：
2.5
通讯作者：
Dym, Martin
中科院分区：
文献类型：
--
作者：
He, Zuping;Kokkinaki, Maria;Dym, Martin
精子发生是指精原干细胞（spermatogenialstemcells，SSCs）分裂、分化为成熟精子的过程。精原干细胞是位于哺乳动物睾丸基底膜上的A型精原细胞亚群。精原干细胞的自我更新和分化是正常精子发生的基础，因此更好地了解精原干细胞的分子机制和信号通路对于精子发生的调节至关重要，并可能最终为男性避孕以及基因治疗带来新的靶点。男性不育和睾丸癌的治疗。揭示的分子机制也非常感兴趣，以更好地了解SSC老化和发展新的治疗策略，退行性疾病的最近的工作表明多能潜力的SSC。最近在阐明决定精原干细胞命运决定的信号分子和途径方面取得了进展。在这篇综述中，我们首先讨论了精原干细胞的形态学特征，表型特征和潜力。然后重点介绍了精原干细胞自我更新和分化的关键信号分子和关键信号通路的研究进展。本文还讨论了信号分子和级联反应的异常表达与精子发生异常和睾丸癌的关系。最后指出了精原干细胞信号通路的研究方向。
Spermatogenesis is the process that involves the division and differentiation of spermatogonial stem cells (SSCs) into mature spermatozoa. SSCs are a subpopulation of type A spermatogonia resting on the basement membrane in the mammalian testis. Self-renewal and differentiation of SSCs are the foundation of normal spermatogenesis, and thus a better understanding of molecular mechanisms and signaling pathways in the SSCs is of paramount importance for the regulation of spermatogenesis and may eventually lead to novel targets for male contraception as well as for gene therapy of male infertility and testicular cancer. Uncovering the molecular mechanisms is also of great interest to a better understanding of SSC aging and for developing novel therapeutic strategies for degenerative diseases in view of the recent work demonstrating the pluripotent potential of the SSC. Progress has recently been made in elucidating the signaling molecules and pathways that determine cell fate decisions of SSCs. In this review, we first address the morphological features, phenotypic characteristics, and the potential of SSCs. And then we focus on the recent advances in defining the key signaling molecules and crucial signaling pathways regulating self-renewal and differentiation of SSCs. The association of aberrant expression of signaling molecules and cascades with abnormal spermatogenesis and testicular cancer are also discussed. Finally we point out potential future directions to pursue in research on signaling pathways of SSCs.
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