Association of Metabolically Healthy Obesity with Subclinical Coronary Atherosclerosis in a Korean Population
Association of Metabolically Healthy Obesity with Subclinical Coronary Atherosclerosis in a Korean Population
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DOI：
10.1002/oby.20883
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发表时间：
2014-12-01
期刊：
影响因子：
6.9
通讯作者：
Lee, Woo Je
中科院分区：
文献类型：
--
作者：
Jung, Chang Hee;Lee, Min Jung;Lee, Woo Je
冠状动脉多探测器计算机断层扫描（MDCT）检测的亚临床冠状动脉粥样硬化的程度在四个组中定义的代谢健康和肥胖的状态在一个无症状的韩国populations.MethodsThe数据的4009无症状的受试者参加了常规的健康筛查检查进行了比较。通过MDCT评估定义为>50%狭窄的显著冠状动脉狭窄、斑块和冠状动脉钙化评分（CACS）。参与者分层的BMI（截止值，25 kg/m2）和代谢健康状态，这是由Wildman criterions.ResultsMetabolically健康的肥胖（MHO）的定义相比，代谢健康的非肥胖（MHNO）受试者有显着较高的患病率显着亚临床冠状动脉粥样硬化的负担。MHO组各种冠状动脉MDCT结果的校正比值比（MHNO组为对照组）冠状动脉狭窄、任何斑块、钙化斑块、混合斑块、CACS > 0、CACS > 100等的发生率分别为1.87（95%CI 1.15-3.03）、1.31（1.01-1.71）、1.40（1.05-1.86）、1.57（1.01-2.48）、1.38（1.04-1.82）和1.69（1.03-2.78）。因此，在评估心血管风险时，考虑代谢健康状态和肥胖是重要的。
ObjectiveThe degree of subclinical coronary atherosclerosis detected by coronary multidetector computed tomography (MDCT) in four groups defined by the state of metabolic health and obesity in an asymptomatic Korean population was compared.MethodsThe data of 4009 asymptomatic subjects who participated in a routine health screening examination were collected. Significant coronary artery stenosis defined as >50% stenosis, plaque, and coronary artery calcium scores (CACS) were assessed by MDCT. Participants were stratified by BMI (cut-off value, 25 kg/m(2)) and metabolically healthy state, which was defined by Wildman criteria.ResultsMetabolically healthy obese (MHO) subjects had a significantly higher prevalence of significant subclinical coronary atherosclerotic burden compared with metabolically healthy nonobese (MHNO) subjects. The adjusted odds ratios of the MHO group for various coronary MDCT findings (MHNO group as the reference), such as coronary artery stenosis, any plaque, calcified plaque, mixed plaque, CACS > 0, and CACS > 100, were 1.87 (95% CI 1.15-3.03), 1.31 (1.01-1.71), 1.40 (1.05-1.86), 1.57 (1.01-2.48), 1.38 (1.04-1.82), and 1.69 (1.03-2.78), respectively.ConclusionsOur data illustrate that MHO subjects have substantial subclinical coronary atherosclerotic burden. Thus, it is important to consider the metabolic health state and obesity in evaluating cardiovascular risk.