In Vitro Activity of Fosfomycin against blaKPC-Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin
In Vitro Activity of Fosfomycin against blaKPC-Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin
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DOI：
10.1128/aac.01235-09
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Bonomo, Robert A.
中科院分区：
文献类型：
--
作者：
Endimiani, Andrea;Patel, Gopi;Bonomo, Robert A.
研究了磷霉素对68株具有bla（KPC）的肺炎克雷伯菌（KpKPC）的体外活性，其中包括23株对替加环素和/或粘菌素不敏感的菌株。琼脂稀释后，93%的KpKPC敏感（MIC50/90分别为16/64 μ g/ml）。23株替加环素和/或粘菌素不敏感菌株的亚组易感率为87% （MIC50/90分别为32/128 μ g/ml）。值得注意的是，6例极耐药（替加环素和粘菌素不敏感）的KpKPC中有5例对磷霉素敏感。与琼脂稀释法相比，圆盘扩散法比Etest法更准确。
In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC50/90 of 16/64 mu g/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC50/90 of 32/128 mu g/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.