A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms
A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms
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DOI：
10.1039/d2re00219a
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发表时间：
2022-07-13
影响因子：
3.9
通讯作者：
Allott, Louis
中科院分区：
文献类型：
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作者：
Barnes, Chris;Nair, Manoj;Allott, Louis
正电子发射断层扫描（PET）放射化学的自动化使用基于暗盒的自动化放射合成平台是绝大多数基于F-18的放射性药物临床转化的重要组成部分。该技术被符合良好生产规范（GMP）的放射性药物生产设施和开发用于临床研究的新型示踪剂的研究机构广泛采用。尽管自动化是临床翻译的基础，但向外行介绍放射化学这一分支的教育资源是有限的。具有自动化功能的出版物假设以前使用这些平台的经验，因此，它们提供的详细信息可能不足以满足新手用户的需求。在这个项目中，我们的目标是弥合这一知识差距，并为所有经验水平的放射化学家提供有效的自动化资源。
The automation of positron emission tomography (PET) radiochemistry using cassette-based automated radiosynthesis platforms is an essential component of clinical translation for the vast majority of F-18-based radiopharmaceuticals. The technology is widely adopted by good manufacturing practice (GMP) compliant radiopharmaceutical production facilities and research institutions developing novel tracers for clinical studies. Despite automation being fundamental to clinical translation, educational resources which introduce this branch of radiochemistry to the uninitiated are limited. Publications featuring automation assume previous experience of using these platforms and therefore, the detail they provide may not be sufficient for a novice user. In this Tutorial Account, we aim to bridge this knowledge gap and provide a resource for efficient automation for radiochemists across all levels of experience.