High-risk personal networks and syringe sharing as risk factors for HIV infection among new drug injectors
High-risk personal networks and syringe sharing as risk factors for HIV infection among new drug injectors
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DOI：
10.1097/00042560-199604150-00011
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发表时间：
1996-01-01
期刊：
影响因子：
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通讯作者：
DesJarlais, DC
中科院分区：
文献类型：
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作者：
Neaigus, A;Friedman, SR;DesJarlais, DC
在一项针对纽约市174名注射吸毒者（IDUs）的横断面研究中，我们调查了那些既共用注射器又有包括高风险注射者在内的个人风险网络的人是否特别容易感染艾滋病毒。研究对象于1991年7月至1993年1月在街头招募，对其前2年的危险行为和前30天内与其他注射吸毒者的个人风险网络进行访谈，并进行HIV检测；20%为HIV血清阳性。在那些共用注射器和有个人风险网络成员每天注射一次以上的人中，40%的HIV血清阳性（而其他人为14%，p < 0.001）。在同时进行的多重逻辑回归中，共用注射器和有个人风险网络成员每天注射一次以上的相互作用仍然是独立的，并且与艾滋病毒血清阳性（OR, 3.57; 95% CI, 1.22, 10.43; p < 0.020）以及拉丁裔种族/民族和交换金钱或毒品的性行为显著相关。这些发现表明，共用注射器与拥有高风险个人网络的结合是新注射吸毒者感染艾滋病毒的一个危险因素。研究新注射吸毒者感染艾滋病毒的危险因素和减少艾滋病毒在他们中间传播的干预措施应侧重于他们的风险网络及其风险行为。
In a cross-sectional study of 174 new injecting drug users (IDUs) in New York City who had injected for less than or equal to 6 years, we examined whether those who both share syringes and have personal risk networks that include high-risk injectors are particularly likely to be infected with HIV. Subjects were street recruited between July 1991 and January 1993, were interviewed about their risk behaviors in the prior 2 years and their personal risk networks with other IDUs in the prior 30 days, and were tested for HIV; 20% were HIV seropositive. Among those who both shared syringes and had a personal risk network member who injected more than once a day, 40% were HIV seropositive (versus 14% for others, p < 0.001). In simultaneous multiple logistic regression, the interaction of both sharing syringes and having a personal risk network member who injected more than once a day remained independently and significantly associated with being HIV seropositive (OR, 3.57; 95% CI, 1.22, 10.43; p < 0.020), along with Latino race/ethnicity and exchanging sex for money or drugs. These findings suggest that the combination of sharing syringes with having a high-risk personal network is a risk factor for HIV infection among new IDUs. Studies of risk factors for HIV infection among new IDUs and interventions to reduce the spread of HIV among them should focus on their risk networks as well as their risk behaviors.