Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants.
Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants.
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DOI：
10.1155/2015/728046
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发表时间：
2015
期刊：
影响因子：
4.2
通讯作者：
Chun OK
中科院分区：
文献类型：
--
作者：
Vance TM;Azabdaftari G;Pop EA;Lee SG;Su LJ;Fontham ET;Bensen JT;Steck SE;Arab L;Mohler JL;Chen MH;Koo SI;Chun OK
背景。前列腺癌是最常见的非皮肤癌，也是美国男性癌症相关死亡的第二大原因。越来越多的证据表明氧化应激与前列腺癌有关。方法。在这项研究中，硫氧还蛋白 1 (Trx 1) 是一种氧化还原状态的酶和亚细胞指示剂，在来自北卡罗来纳州-路易斯安那州前列腺癌项目的 55 名男性的前列腺活检组织中进行了测量。病理学家对 Trx 1 水平进行盲评分。使用 Fisher 精确检验确定 Trx 1 与格里森评分、红细胞抗氧化酶活性和膳食抗氧化剂摄入量之间的关联。结果。患有前列腺癌的男性良性前列腺组织中的 Trx 1 水平与格里森评分呈正相关 (P = 0.01)，与膳食抗氧化剂摄入量呈负相关 (P = 0.03)。在前列腺癌组织中，Trx 1 水平与红细胞谷胱甘肽过氧化物酶活性相关（P = 0.01）。没有发现与其他红细胞酶的关联。恶性组织的格里森评分越高，恶性组织和良性组织之间的 Trx 1 水平差异越大 (P = 0.04)。结论。这些结果表明前列腺组织的氧化还原状态与前列腺癌分级以及内源性和外源性抗氧化剂相关。
Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher's exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P = 0.01) and inversely associated with dietary antioxidant intake (P = 0.03). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P = 0.01). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P = 0.04). Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.