The contributions of ON- and OFF-pathways to contrast sensitivity and spatial resolution in goldfish.
The contributions of ON- and OFF-pathways to contrast sensitivity and spatial resolution in goldfish.
复制标题
ON-和OFF-通路对金鱼对比灵敏度和空间分辨率的贡献。
DOI：
10.1016/0042-6989(94)e0044-l
复制
发表时间：
1995
期刊：
影响因子：
1.8
通讯作者：
Powers,MK
中科院分区：
文献类型：
--
作者：
Bilotta,J;DemarcoJr,PJ;Powers,MK
dl-2-氨基-4-膦酰基丁酸（APB）可降低金鱼视网膜的ON-和OFF-反应的敏感性，但ON-反应的降低程度明显大于OFF-反应。本文研究了空间正弦光栅对金鱼行为敏感性的影响。鱼类经典的条件反射，以抑制呼吸光栅漂移在1赫兹的介绍，对比度阈值进行了测量，由一个基于两个替代的强迫选择程序。在眼内注射APB或生理盐水后重复牵拉。生理盐水没有影响，但APB显着降低对比敏感度，并将对比敏感度功能转移到较低的空间频率。结果表明，ON-和OFF-通路是必要的正常的空间视觉和APB的影响是一致的ON-和OFF-通路的中断。
dl-2-amino-4-phosphonobutyric acid (APB) reduces the sensitivity of ON- and OFF-responses in goldfish retina, although the ON-responses are reduced significantly more than the OFF-responses. This paper describes the effects of APB on behavioral sensitivity of goldfish to spatial sinusoidal gratings. Fish were classically conditioned to suppress respiration upon presentation of gratings drifting at 1 Hz; contrast thresholds were measured by an observer-based two-alternative forced-choice procedure. Thresholds were repeated following intraocular injections of APB or physiological saline. Saline had no effect, but APB dramatically reduced contrast sensitivity and shifted contrast sensitivity functions to lower spatial frequencies. The results suggest that both ON- and OFF-pathways are necessary for normal spatial vision and that the effects of APB are consistent with the disruption of both ON- and OFF-pathways.