LOGISTIC DISCRIMINANT-ANALYSIS OF LIPIDS AND APOLIPOPROTEINS IN A POPULATION OF CORONARY-BYPASS PATIENTS AND THE SIGNIFICANCE OF APOLIPOPROTEIN-C-III AND APOLIPOPROTEIN-E
LOGISTIC DISCRIMINANT-ANALYSIS OF LIPIDS AND APOLIPOPROTEINS IN A POPULATION OF CORONARY-BYPASS PATIENTS AND THE SIGNIFICANCE OF APOLIPOPROTEIN-C-III AND APOLIPOPROTEIN-E
复制标题
DOI：
10.1016/0021-9150(90)90042-h
复制
发表时间：
1990-06-01
期刊：
影响因子：
5.3
通讯作者：
FRUCHART, JC
中科院分区：
文献类型：
--
作者：
CHIVOT, L;MAINARD, F;FRUCHART, JC
74名男性（平均年龄49.96 ± 1.00岁）的脂质和载脂蛋白状态。5.9年龄48.88 ± 1.28岁），并将其结果与对照组78名男性（平均年龄48.88 ± 1.28岁）的结果进行比较。5.41年）。使用伴刀豆球蛋白A试剂分离含（Lp B）和不含（非Lp B）apo B的微粒，测定载脂蛋白C-III（apo C-III）和E（apo E）。载脂蛋白C-Ⅲ在LpB颗粒中显著升高（P < 0.001），载脂蛋白E在LpB（P < 0.001）和非LpB（P < 0.001）颗粒中显著升高。Logistic逐步判别分析中选择的显著变量为总胆固醇/HDL-胆固醇、apo E-nonLpB和apo C-III-LpB。这最后一个参数，这是更具判别力的甘油三酯，提供了一个更具体的指标异常脂蛋白血症的冠状动脉旁路移植术患者，与其他变量，它显着提高了正确分类的个人的百分比。
The lipid and apolipoprotein states of 74 men (mean age 49.96 .+-. 5.9 years) were studied 24 h before coronary bypass surgery and their results wree compared with those of a control group of 78 men (mean age 48.88 .+-. 5.41 years). Apolipoproteins C-III (apo C-III) and E (apo E) were determined in particles with (LpB) and without (non-LpB) apo B separated using a concanavalin A reagent. Apo C-III was significantly increased in LpB particles (P < 0.001), and apo E in LpB (P < 0.001) and nonLpB (P < 0.001) particles. The significant variables selected in logistic discriminant stepwise analysis were total cholesterol/HDL-cholesterol, apo E-nonLpB and apo C-III-LpB. This last parameter, which is more discriminant than triglycerides, provides a more specific indication of dyslipoproteinemia in coronary bypass patients; in association with the other variables, it significantly improved the percentage of correctly classified individuals.