PET measurement of changes in D2/D3 dopamine receptor binding in a nonhuman primate during chronic deep brain stimulation of the bed nucleus of the stria terminalis.
PET measurement of changes in D2/D3 dopamine receptor binding in a nonhuman primate during chronic deep brain stimulation of the bed nucleus of the stria terminalis.
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PET 测量非人类灵长类动物在终纹床核慢性深部脑刺激过程中 D2/D3 多巴胺受体结合的变化。
DOI：
10.1016/j.jneumeth.2008.08.033
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发表时间：
2009
影响因子：
3
通讯作者：
Christian,BradleyT
中科院分区：
文献类型：
--
作者：
Vandehey,NicholasT;Garell,PCharles;Hampel,JosephA;Murali,Dhanabalan;Smith,ElizabethM;Davidson,Richard;Converse,AlexanderK;Nickles,RJerry;Christian,BradleyT
PET imaging is a powerful tool for measuring physiological changes in the brain during deep brain stimulation (DBS). In this work, we acquired five PET scans using a highly selective D2/D3 dopamine antagonist, 18F-fallypride, to track changes in dopamine receptor availability, as measured by the distribution volume ratio (DVR), through the course of DBS in the bed nucleus of the stria terminalis (BNST) in a nonhuman primate.METHODSPET scans were performed on a rhesus monkey with unilateral BNST stimulation during periods of baseline, chronic high frequency (130Hz) and low frequency (50Hz) DBS stimulation, and during a washout period between stimulation periods. A final scan was performed with the electrode stimulation starting 110min into the scan. Whole brain parametric images of18F-fallypride DVR were calculated for each condition to track changes in both striatal and extrastriatal D2/D3 availability.RESULTSThe monkey displayed significant increases in receptor binding throughout the brain during DBS relative to baseline for 130 and 50Hz, with changes in DVR of: caudate 42%, 51%; putamen 56%, 57%; thalamus 33%, 49%; substantia nigra 29%, 26%; and prefrontal cortex 28%, 56%, respectively. Washout and post-stimulation scans revealed DVR values close to baseline values. Activating the stimulator midway through the final scan resulted in no statistically significant changes in binding.CONCLUSIONSPET neuroligand imaging has demonstrated the sensitivity to track changes in dopamine D2/D3 binding during the course of DBS. These methods show great potential for providing insight into the neurochemical consequences of DBS.
