Computational Methods for the Analysis of Primate Mobile Elements
Computational Methods for the Analysis of Primate Mobile Elements
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DOI：
10.1007/978-1-60327-367-1_8
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Batzer, Mark A.
中科院分区：
文献类型：
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作者：
Cordaux, Richard;Sen, Shurjo K.;Batzer, Mark A.
转座因子（TE）被定义为可以在基因组中从一个位点移动到另一个位点的离散DNA片段，是包括灵长类动物在内的真核生物基因组的重要组成部分。比较全基因组分析揭示了TE家族对灵长类基因组的相当大的结构和功能影响。对这些问题的见解部分来自于计算方法的发展，这些方法允许对填充灵长类基因组的许多TE家族进行详细和可靠的识别、注释和进化分析。在这里，我们介绍了这些计算方法的概述，并描述了有效的数据挖掘策略，以提供最新可用的基因组序列中TE生物学的全面图景。
Transposable elements (TE), defined as discrete pieces of DNA that can move from one site to another site in genomes, represent significant components of eukaryotic genomes, including primates. Comparative genome-wide analyses have revealed the considerable structural and functional impact of TE families on primate genomes. Insights into these questions have come in part from the development of computational methods that allow detailed and reliable identification, annotation, and evolutionary analyses of the many TE families that populate primate genomes. Here, we present an overview of these computational methods and describe efficient data mining strategies for providing a comprehensive picture of TE biology in newly available genome sequences.