A midline dissociation between error-processing and response-conflict monitoring
A midline dissociation between error-processing and response-conflict monitoring
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DOI：
10.1016/s1053-8119(03)00334-3
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发表时间：
2003-10-01
期刊：
影响因子：
5.7
通讯作者：
Stein, EA
中科院分区：
文献类型：
--
作者：
Garavan, H;Ross, TJ;Stein, EA
错误之后的中线脑激活被认为反映了错误检测，或者是冲突监控过程。在这些替代方案之间进行裁决是具有挑战性的，因为两者都预测错误试验的高激活。为了解决这些解释，被试完成了一个GO/NOGO任务，在该任务中，指令错误频繁，反应冲突通过操纵反应速度而独立变化。混合块和事件相关的fMRI设计确定了正确和错误试验的任务相关激活、强直激活和事件相关激活。前扣带是唯一一个不受冲突操作调节的错误相关激活区域，因此与特定的错误相关过程有关。相反，前sma的激活并不特定于错误，而是对冲突操作敏感。在这两个中线区域之间，有一个显著的冲突相互作用区域支持张力激活的功能分离。最后，一个中间的尾端扣带区参与错误处理和冲突监测。结果表明，这两个动作监测过程是不同的，可分离的，并沿中线定位。(C) 2003 Elsevier Inc.版权所有。
Midline brain activation subsequent to errors has been proposed to reflect error detection and, alternatively, conflict-monitoring processes. Adjudicating between these alternatives is challenging as both predict high activation on error trials. In an effort to resolve these interpretations, subjects completed a GO/NOGO task in which errors of commission were frequent and response conflict was independently varied by manipulating response speeds. A mixed-block and event-related fMRI design identified task-related, tonic activation and event-related activations for correct and incorrect trials. The anterior cingulate was the only area with error-related activation that was not modulated by the conflict manipulation and hence is implicated in specific error-related processes. Conversely, activation in the pre-SMA was not specific to errors but was sensitive to the conflict manipulation. A significant region by conflict interaction for tonic activation supported a functional dissociation between these two midline areas. Finally, an intermediate, caudal cingulate area was implicated in both error processing and conflict monitoring. The results suggest that these two action-monitoring processes are distinct and dissociable and are localised along the midline. (C) 2003 Elsevier Inc. All rights reserved.