Photodynamic therapy: oncologic horizons
Photodynamic therapy: oncologic horizons
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DOI：
10.2217/fon.13.176
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发表时间：
2014-01-01
期刊：
影响因子：
3.3
通讯作者：
Allison, Ron R.
中科院分区：
文献类型：
--
作者：
Allison, Ron R.
光动力疗法（PDT）是一种基于光的干预，在肿瘤和非恶性肿瘤方面都有长期成功的临床记录。在癌症患者中，静脉内、口服或局部施用光敏剂，并允许时间优先在肿瘤区域中积累。然后将具有适当波长和强度的光引入肿瘤床，以激活所采用的特定光敏剂。光能将激活光敏剂，其在氧存在下应允许产生产生活性氧物质的毒性光动力反应。光动力学反应产生一系列级联事件，包括肿瘤和新生血管中的凋亡和坏死途径的启动，导致永久性病变破坏，通常伴随免疫系统的上调。非故意阳光照射引起的皮肤光毒性仍然是PDT最常见的发病率。本文将重点介绍目前的研究和成果，从基础科学和肿瘤PDT的临床应用，并解释这些发现可能会导致增强和完善未来的PDT。
Photodynamic therapy (PDT) is a light-based intervention with a long and successful clinical track record for both oncology and non-malignancies. In cancer patients, a photosensitizing agent is intravenously, orally or topically applied and allowed time to preferentially accumulate in the tumor region. Light of the appropriate wavelength and intensity to activate the particular photosensitizer employed is then introduced to the tumor bed. The light energy will activate the photosensitizer, which in the presence of oxygen should allow for creation of the toxic photodynamic reaction generating reactive oxygen species. The photodynamic reaction creates a cascading series of events including initiation of apoptotic and necrotic pathways both in tumor and neovasculature, leading to permanent lesion destruction often with upregulation of the immune system. Cutaneous phototoxicity from unintentional sunlight exposure remains the most common morbidity from PDT. This paper will highlight current research and outcomes from the basic science and clinical applications of oncologic PDT and interpret how these findings may lead to enhanced and refined future PDT.