Plasmids and pheromone response of the beta-lactamase producer Streptococcus (Enterococcus) faecalis HH22
Plasmids and pheromone response of the beta-lactamase producer Streptococcus (Enterococcus) faecalis HH22
复制标题
DOI：
10.1128/aac.32.4.547
复制
发表时间：
1988-04
影响因子：
4.9
通讯作者：
B. E. Murray;F. An;D. Clewell
中科院分区：
文献类型：
--
作者：
B. E. Murray;F. An;D. Clewell
粪链球菌（肠球菌）HH 22是一种临床分离株，可产生β-内酰胺酶，并对多种其他抗菌剂具有耐药性。在本研究中，发现HH 22含有三个接合质粒和一个接合转座子。pBEM 10编码β-内酰胺酶、庆大霉素抗性和对肽信息素cAD 1的应答; pAM 323编码红霉素抗性; pAM 324编码未知抗性。后两种质粒对称为cAM 323和cAM 324的信息素有反应，这两种信息素与其它先前表征的信息素无关。pBEM 10和pAM 323是赋予性信息素应答的天然存在的R质粒的第二和第三个实例。
Streptococcus (Enterococcus) faecalis HH22 is a clinical isolate that produces beta-lactamase and is resistant to various other antimicrobial agents. In this study, HH22 was found to contain three conjugative plasmids and a conjugative transposon. pBEM10 encodes beta-lactamase, gentamicin resistance, and a response to the peptide pheromone cAD1; pAM323 encodes erythromycin resistance; and pAM324 encodes no known resistance. The latter two plasmids respond to pheromones designated cAM323 and cAM324 which are unrelated to other previously characterized pheromones. pBEM10 and pAM323 are the second and third examples of naturally occurring R plasmids that confer a sex pheromone response.