Compressive properties of cd-HA-gelatin modified intrasynovial tendon allograft in canine model in vivo.
Compressive properties of cd-HA-gelatin modified intrasynovial tendon allograft in canine model in vivo.
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DOI：
10.1016/j.jbiomech.2010.12.030
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发表时间：
2011-06-03
影响因子：
2.4
通讯作者：
Amadio PC
中科院分区：
文献类型：
--
作者：
Ikeda J;Zhao C;Chen Q;Thoreson AR;An KN;Amadio PC
虽然我们有时使用滑膜内同种异体肌腱作为供体，但冻干制备的同种异体肌腱的滑动能力明显降低。肌腱重建后，移植物肌腱的滑动能力非常重要，因为较高的滑动阻力会导致更多的粘连，导致临床效果不佳。我们最近发现，用碳二亚胺衍生透明质酸(cd-HA)-明胶混合物处理肌腱表面可显著提高滑膜内同种异体肌腱移植物的滑动能力。本研究的目的是探讨cd- ha -明胶处理是否会影响肌腱的力学性能。采用压痕试验对40根犬指深屈肌腱的抗压性能进行了评价。测量正常肌腱、冻干后再水合肌腱、体内移植6周的冻干后再水合肌腱和体内移植6周的cd-HA处理过的冻干后再水合肌腱的压痕刚度。结果显示，各组肌腱抗压性能无显著差异。这些结果表明，cd-HA治疗滑膜内同种异体肌腱是一种很好的方法，可以在不改变供肌腱压缩特性的情况下提高冻干后肌腱的滑动能力。
Although we sometimes use the intrasynovial tendon allograft as a donor, the gliding ability of allograft prepared by lyophilization is significantly decreased. The gliding ability of the grafted tendon after tendon reconstruction is very important because the high gliding resistance causes more adhesion and leads to poor clinical results. We recently revealed that tendon surface treatment with a carbodiimide derivatized HA (cd-HA)-gelatin mixture for intrasynovial tendon allograft significantly improved its gliding ability. The purpose of this study was to investigate whether this cd-HA-gelatin treatment affects the tendon mechanical property or not. A total of 40 flexor digitorum profundus (FDP) tendons from canines were evaluated for compressive property by using indentation test. Indentation stiffness was measured for normal tendon, rehydrated tendon after lyophilization, rehydrated tendon after lyophilization that was implanted 6 weeks in vivo, and cd-HA treated rehydrated tendon after lyophilization that was implanted 6 weeks in vivo. The results for all groups showed no significant difference in the tendon compressive properties. The findings of these results demonstrate that cd-HA treatment for intrasynovial tendon allograft is an excellent method to improve the tendon gliding ability after lyophilization without changing the compressive property of donor tendon.