Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy
Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy
复制标题
老年病理II期和III期胃癌患者根治性胃切除术后的生存结果
DOI：
10.1002/ags3.12339
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发表时间：
2020
影响因子：
2.7
通讯作者：
Sano Takeshi
中科院分区：
文献类型：
--
作者：
Takahashi Ryo;Nunobe Souya;Makuuchi Rie;Ida Satoshi;Kumagai Koshi;Ohashi Manabu;Sano Takeshi
目的病理分期为II期和III期的老年胃癌患者的生存结局仍不清楚。我们回顾性分析了老年和非老年患者进行根治性胃切除术的这种癌症的结局，并考虑了生理能力和手术压力（E-PASS）评分系统的估计的临床结果prediction.MethodsAmong 1041 pStages II和III胃癌行胃切除术在2008年和2013年之间连续，898例患者入组。其中，158例患者（17.6%）是老年人和740例患者（82.4%）是nonelder.ResultsDisease-specific survival（DSS）在老年组pStage III癌症是显着不如在同一阶段nonelderly组（P= 0.001），而有没有在pStage II癌症组之间的DSS差异（P= 0.45）。对于pII期和III期，老年患者的总生存期（OS）显著更差。与pStage III癌症患者相比，pStage II癌症老年患者OS和DSS之间的生存差距更大。pII期胃癌中CRS> 0.159的老年患者的OS显著低于CRS ≤ 0.159的老年患者。老年患者的OS和DSS之间的生存差距在pStage II癌症中大于pStage III癌症。E-PASS评分系统可能是老年患者中相对有用的预测因子。
AimSurvival outcomes in elderly patients with pathological stages (pStages) II and III gastric cancer remain inadequately elucidated. We retrospectively analyzed outcomes of elderly and nonelderly patients who underwent curative gastrectomy for this cancer and considered clinical results of the Estimation of Physiologic Ability and Surgical Stress (E‐PASS) scoring system for prediction.MethodsAmong 1041 patients who underwent gastrectomy for pStages II and III gastric cancer between 2008 and 2013 consecutively, 898 patients were enrolled. Of these, 158 patients (17.6%) were elderly and 740 patients (82.4%) were nonelderly.ResultsDisease‐specific survival (DSS) in the elderly group with pStage III cancer was significantly worse than that in the same stage nonelderly group (P= .001), while there was no difference in DSS for pStage II cancer between the groups (P= .45). Overall survival (OS) was significantly worse in elderly patients for both pStages II and III. Elderly patients with pStage II cancer had larger survival gaps between OS and DSS compared with those with pStage III cancer. OS for elderly patients with comprehensive risk score (CRS) > 0.159 was significantly worse than that for elderly patients with CRS ≤ 0.159 in pStage II cancer.ConclusionsCompared with nonelderly patients, different characteristics were observed in the survival outcomes of elderly patients between pStages II and III gastric cancer. The survival gap between OS and DSS of elderly patients was larger in pStage II cancer than in pStage III cancer. The E‐PASS scoring system could be a relatively useful predictor in elderly patients.