Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial
Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial
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DOI：
10.3390/nu12010225
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发表时间：
2020-01-01
期刊：
影响因子：
5.9
通讯作者：
Vandenplas, Yvan
中科院分区：
文献类型：
--
作者：
Kubota, Megumi;Ito, Kazuya;Vandenplas, Yvan
目的：慢性功能性便秘是一种常见的疾病。本研究的目的是评估益生菌乳酸杆菌（L.）reuteri DSM 17938和氧化镁（MgO）用于缓解儿童慢性功能性便秘。研究设计：在日本的5家儿科门诊进行了一项前瞻性、双盲、安慰剂对照、随机和平行组试验。根据罗马IV标准，选择6个月以上6岁以下功能性便秘患儿60例，随机分为3组：A组20例，给予L. reuteri DSM 17938和作为MgO安慰剂的乳糖水合物; B组（n = 19）接受L. reuteri DSM 17938和MgO; reuteri DSM 17938和MgO。结果如下：所有三组在第四周与基线状况相比排便频率均表现出显著改善（A组：p < 0.05; B组：p < 0.05; C组：p < 0.05）。MgO组和联合用药组粪便粘稠度明显下降，而L。罗伊氏DSM 17938组则没有（A组：p = 0.079; B组：p < 0.05; C组：p < 0.05）。氧化镁显着抑制属小类杆菌的存在。排便频率与肠道微生物组中梭菌属细菌的频率呈负相关。结论：L. Rueteri DSM 17938和MgO在幼儿功能性便秘的管理中均有效。MgO导致胃肠道微生物组失衡，而益生菌组的情况并非如此。
Objective: Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium oxide (MgO) for relieving chronic functional constipation in children. Study design: A prospective, double-blind, placebo-controlled, randomized, and parallel-group trial was conducted in five pediatric outpatient clinics in Japan. Sixty patients who were more than six months old and under six years of age with a diagnosis of functional constipation according to Rome IV criteria were randomly divided into three groups: group A (n = 20) received L. reuteri DSM 17938 and lactose hydrate as a placebo of MgO; group B (n = 19) received L. reuteri DSM 17938 and MgO; and group C (n = 21) received a placebo of L. reuteri DSM 17938 and MgO. Results: All three groups exhibited significant improvement in defecation frequency in the fourth week compared with the baseline condition (group A: p < 0.05; group B: p < 0.05; group C: p < 0.05). The MgO group and combination group showed a significant decrease in stool consistency, but the L. reuteri DSM 17938 group did not (group A: p = 0.079; group B: p < 0.05; group C: p < 0.05). MgO significantly suppressed the presence of the genus Dialister. Defecation frequency negatively correlated with the frequency of Clostridiales-belonging bacteria among the gut microbiome. Conclusions: L. rueteri DSM 17938 and MgO were both effective in the management of functional constipation in young children. MgO caused an imbalance in the gastrointestinal microbiome, which was not the case in the probiotic group.