Aberrant expression of T-cell-associated antigens on B-cell non-Hodgkin lymphomas.
Aberrant expression of T-cell-associated antigens on B-cell non-Hodgkin lymphomas.
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B 细胞非霍奇金淋巴瘤上 T 细胞相关抗原的异常表达。
DOI：
10.1309/v8yg-8pp4-b4te-9x6j
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发表时间：
2001
影响因子：
3.5
通讯作者：
M. Zutter
中科院分区：
文献类型：
--
作者：
Z. Kaleem;G. White;M. Zutter
我们描述了 9 例特征明确的 B 细胞非霍奇金淋巴瘤 (NHL) 病例，通过 2 色流式细胞术显示 T 细胞相关抗原的异常表达。病例如下：慢性淋巴细胞白血病/小淋巴细胞淋巴瘤4例；滤泡中心细胞淋巴瘤，2；套细胞淋巴瘤，1；和弥漫性大B细胞淋巴瘤，2. CD2是最常表达的抗原（5例）。 2例中各检测到CD8和CD7，其中1例同时表达CD7和CD4。病程和治疗反应与淋巴瘤的类型和阶段相一致。在任何情况下都没有发现异常的攻击性行为。同期分析的59例良性淋巴结对照组未显示T细胞相关抗原的异常表达；因此，这种表达不是良性淋巴增殖的特征。对这些 B 细胞淋巴瘤的研究对于研究沉默或抑制的 T 细胞分化基因的异常激活可能具有无价的价值。表达 CD2 的 B 细胞 NHL 可能代表 CD2+ B 淋巴细胞的克隆扩增，这些淋巴细胞通常构成外周 B 淋巴细胞的一小部分，不应与复合 B 细胞和 T 细胞淋巴瘤相混淆。除非持续地注意到攻击性行为，否则任何攻击性治疗都是不合理的。
We describe 9 well-characterized cases of B-cell non-Hodgkin lymphoma (NHL) that showed aberrant expression of T-cell-associated antigens by 2-color flow cytometry. Cases were as follows: chronic lymphocytic leukemia/small lymphocytic lymphoma, 4; follicle center cell lymphoma, 2; mantle cell lymphoma, 1; and diffuse large B-cell lymphoma, 2. CD2 was the most commonly expressed antigen (5 cases). CD8 and CD7 were identified in 2 cases each, including 1 case that expressed both CD7 and CD4. The disease course and response to treatment were compatible with the type and stage of lymphoma. No unusually aggressive behavior was noted in any case. A control group of 59 cases of benign lymph nodes analyzed during the same period showed no aberrant expression of T-cell-associated antigens; thus, such expression is not a feature of benign lymphoid proliferations. Study of these B-cell lymphomas may prove invaluable to study aberrant activation of silent or repressed T-cell differentiation genes. CD2-expressing B-cell NHLs may represent clonal expansion of CD2+ B lymphocytes that normally constitute a small fraction of peripheral B lymphocytes and should not be confused with composite B- and T-cell lymphomas. Unless aggressive behavior is noted consistently, no aggressive treatment is justified.
单克隆抗羊红细胞抗体导致 B 细胞慢性淋巴细胞白血病中虚假 E 玫瑰花结的形成。
影响因子：
20.3
作者：
Mills,LE;O'Donnell,JF;Guyre,PM;LeMarbre,PJ;Miller,JD;Bernier,GM
通讯作者：
Bernier,GM