Diketopyrrolopyrrole-derived organic small molecular dyes for tumor phototheranostics
Diketopyrrolopyrrole-derived organic small molecular dyes for tumor phototheranostics
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DOI：
10.1016/j.cclet.2021.10.054
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发表时间：
2022-04-22
影响因子：
9.1
通讯作者：
Shao, Jinjun
中科院分区：
文献类型：
--
作者：
Ma, Qianli;Sun, Xu;Shao, Jinjun
癌症是全世界人类死亡的主要原因之一。光疗法包括光动力疗法（PDT）和光热疗法（PTT），是一种新兴的光触发肿瘤治疗方法，具有无创、副作用小等优点。设计和制备高效的光疗剂对光疗具有重要意义。二酮基吡咯并吡咯（DPP）是一种小分子有机染料，具有优异的光物理性质、结构和性质易于调节、光稳定性好等特点，因此，基于DPP衍生物的光治疗剂不仅在光治疗方面，而且在荧光成像（FLI）和光声成像（派）的光诊断方面都受到了广泛的关注。本文综述了近五年来各种基于DPP的有机小分子在光治疗诊断中的研究进展。详细讨论了它们的分子结构设计及其光治疗诊断学性能，为进一步开发基于DPP的光治疗诊断学奠定了基础。(C)2021由Elsevier B.V.代表中国化学会和中国医学科学院药物研究所出版。
Cancer is one of the leading causes of human death around the world. Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is an emerging light-triggered cancer treatment and shows the advantages of non-invasiveness and low side effects. The design and preparation of efficient phototherapeutic agents are of great significance for phototherapy. Diketopyrrolopyrrole (DPP) is a small molecular organic dye featuring outstanding photophysical properties, facile tuning of structures and properties, and excellent photostability; thus, phototherapeutic agents based on organic small molecular DPP derivatives have attracted significant research attention for not only phototherapy but also photodiagnosis of fluorescence imaging (FLI) and photoacoustic imaging (PAI). This review summarizes the recent progress of various DPP-based organic small molecules on phototheranostics during the last five years. The molecular structure design and their phototheranostics performances are discussed in detail, as will be of great help for further creation of DPP-based phototheranostics. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.