High Frequency Activity in the Orbital Frontal Cortex Modulates with Mismatched Expectations During Gambling in Humans
High Frequency Activity in the Orbital Frontal Cortex Modulates with Mismatched Expectations During Gambling in Humans
复制标题
人类赌博期间眶额皮质的高频活动与不匹配的期望进行调节
DOI：
10.1109/embc44109.2020.9175721
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sarma, Sridevi V.
中科院分区：
文献类型：
--
作者：
Gunaratnam, Sejal;Talluri, Dinakar;Greene, Patrick;Sacre, Pierre;Gonzalez-Martinez, Jorge;Sarma, Sridevi V.
在赌博过程中，人们通常首先根据预期的回报和预期的风险做出决定。然而，期望可能与实际结果不符。当赌徒记录自己的表现时，他们可能会或多或少地感到幸运，从而影响未来的赌博决策。研究已经确定眶额皮质（OFC）是一个在人类风险决策中起重要作用的大脑区域。然而，大多数人类研究都是通过功能性磁共振成像（fMRI）来推断神经活动的，这种成像的时间分辨率很差。特别是，fMRI无法检测到OFC神经元群的活动，OFC可能会编码关于受试者对不匹配结果的反应的特定信息。在这项初步研究中，四名受试者参与了一项赌博任务，同时OFC记录了以毫秒分辨率捕获的局部场电位（LFPs）。我们分析了LFPs的高频活动（HFA: bb0 - 70 Hz），因为HFA已被证明与神经元群的激活相关。在四分之三的受试者中，OFC中的HFA在匹配和不匹配的试验中，一旦每次打赌的结果被揭示，就会在不同的时间和方向发生调节，这取决于OFC内的解剖位置。
During gambling, humans often begin by making decisions based on expected rewards and expected risks. However, expectations may not match actual outcomes. As gamblers keep track of their performance, they may feel more or less lucky, which then influences future betting decisions. Studies have identified the orbitofrontal cortex (OFC) as a brain region that plays a significant role during risky decision making in humans. However, most human studies infer neural activation from functional magnetic resonance imaging (fMRI), which has a poor temporal resolution. In particular, fMRI cannot detect activity from neuronal populations in the OFC, which may encode specific information about how a subject reacts to mismatched outcomes. In this preliminary study, four human subjects participated in a gambling task while local field potentials (LFPs), captured at a millisecond resolution, were recorded from the OFC. We analyzed high-frequency activity (HFA: >70 Hz) in the LFPs, as HFA has been shown to correlate to activation of neuronal populations. In 3 out of 4 subjects, HFA in OFC modulated between matched and mismatched trials as soon as the outcome of each bet was revealed, with modulations occurring at different times and directions depending on the anatomical location within the OFC.
眶额皮层的幸运节奏导致人类赌博决策偏差
影响因子：
4.6
作者：
Pierre Sacré;M. Kerr;Kevin Kahn;J. González;Juan Bulacio;Hyun;Matthew A. Johnson;Susan Thompson;Jaes C. Jones;V. Chib;J. Gale;S. Sarma
通讯作者：
S. Sarma