Methods for the Synthesis of Substituted Azetines
Methods for the Synthesis of Substituted Azetines
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DOI：
10.1021/acs.orglett.7b02847
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发表时间：
2017-10-20
期刊：
影响因子：
5.2
通讯作者：
Didier, Dorian
中科院分区：
文献类型：
--
作者：
Baumann, Andreas N.;Eisold, Michael;Didier, Dorian
受最近化学界对不饱和四元杂环的兴趣的刺激，设计了一种前所未有的含氮四元环的方法。从市售的底物合成了3，4-二取代的2-氮杂环丁烷，允许直接访问手性官能化氮杂环丁烷和氨基醇的新库。这种原始的方法被应用于有效地制备官能化偶氮苯，一个新兴的一类分子在药物药理学的巨大潜力。
Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from commercially available substrates, allowing for a straightforWard access to a new library of chiral functionalized azetidines and amino alcohols. This original approach was applied to efficiently prepare functionalized azobenzenes, an emerging class of molecules with a large potential in photopharmacology.