Beyond Aquaporins: Recent Developments in Artificial Water Channels
Beyond Aquaporins: Recent Developments in Artificial Water Channels
复制标题
超越水通道蛋白：人工水道的最新进展
DOI：
10.1021/acs.langmuir.2c01605
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发表时间：
2022
期刊：
影响因子：
3.9
通讯作者：
Kumar, Manish
中科院分区：
文献类型：
--
作者：
Song, Woochul;Kumar, Manish
水通道蛋白（AQPs）在生物水通道中的快速和选择性水运输的分子尺度理解激发了在合成结构中模仿其性能的尝试。这些合成结构，被称为人工水道（awc），在应用中比aqp有几个优点。经过十多年的努力，AQPs独特的输运特性已经在AWCs中重现。此外，最近的发展表明，使用生物学中未见的新特征的新AWC设计可以超越基准AQP通道的性能。在本文中，我们简要概述了AWC的最新发展，并分享了我们对前瞻性AWC研究的看法。
A molecular scale understanding of the fast and selective water transport in biological water channels, aquaporins (AQPs), has inspired attempts to mimic its performance in synthetic structures. These synthetic structures, referred to as artificial water channels (AWCs), present several advantages over AQPs in applications. After over a decade of efforts, the unique transport properties of AQPs have been reproduced in AWCs. Further, recent developments have shown that the performance of benchmark AQP channels can be exceeded by new AWC designs using novel features not seen in biology. In this Perspective, we provide a brief overview of recent AWC developments, and share our perspective on forward-looking AWC research.