Results of experimental endoscopic esophageal varix ligation.
Results of experimental endoscopic esophageal varix ligation.
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实验性内窥镜食管静脉曲张结扎的结果。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Hammond Ws
中科院分区：
文献类型：
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作者：
G. V. Stiegmann;Sun Jh;Hammond Ws
内窥镜下精索静脉曲张结扎术(EVL)是使用柔性胃镜和新近开发的弹力带结扎器进行的。犬静脉曲张直径为3~5 mm。37个静脉曲张部位接受了EVL，其中34个(92%)一次结扎成功。治疗后1~60d大体及光镜检查可见黏膜及粘膜下层缺血坏死(24小时)，急性炎症、存活组织与坏死组织分界，肉芽组织出现(3~7天)，粘膜及粘膜下层全层置换，瘢痕组织成熟，接近完全上皮化(14~21天)，完全愈合(50~60天)。炎症和疤痕组织沉积持续堵塞粘膜下静脉通道，但保留固有肌层完整。没有观察到穿孔或其他不良的临床或组织学影响。EVL治疗犬食道静脉曲张可通过炎症和瘢痕形成过程安全有效地闭塞粘膜下层的血管通道。
Endoscopic Variceal ligation (EVL) is performed using a flexible gastroscope and a recently developed elastic band ligating device. Varices from 3-5 mm in diameter were created in a canine model. Thirty seven variceal sites underwent EVL with successful ligation on first attempt in 34 (92%). Gross and microscopic examination of treated sites at 1-60 days showed ischemic necrosis of mucosa and submucosa (24 hours), acute inflammation, demarcation of viable and necrotic tissue, and appearance of granulation tissue (3-7 days), full thickness replacement of mucosa and submucosa with maturing scar tissue and near complete re-epithelialization (14-21 days), and complete healing (50-60 days). Inflammation and scar tissue deposition consistently obliterated submucosal venous channels but left muscularis propria intact. No perforations or other adverse clinical or histological effects were observed. EVL treatment of canine esophageal varices appears to result in safe and effective obliteration of vascular channels in the submucosa by a process of inflammation and scar formation.