The Exocyst: Dynamic Machine or Static Tethering Complex?
The Exocyst: Dynamic Machine or Static Tethering Complex?
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DOI：
10.1002/bies.201900056
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发表时间：
2019-07-01
期刊：
影响因子：
4
通讯作者：
Nishida-Fukuda, Hisayo
中科院分区：
文献类型：
--
作者：
Nishida-Fukuda, Hisayo
外囊是一种保守的八聚体复合体，在膜融合之前，它物理上将小泡系在质膜上。它不仅对分泌和膜递送很重要，而且在哺乳动物细胞中对胞质分裂、纤毛发生、自噬、肿瘤发生和宿主防御也很重要。基因组编辑和先进的光学显微镜相结合的活细胞胞外胞囊亚单位最近表明，该复合体比以前所认识的更具活力，并暴露了我们对其功能和调节仍然知之甚少。
The exocyst is a conserved octameric complex that physically tethers a vesicle to the plasma membrane, prior to membrane fusion. It is important not only for secretion and membrane delivery but also, in mammalian cells, for cytokinesis, ciliogenesis, autophagy, tumorigenesis, and host defense. The combination of genome editing and advanced light microscopy of exocyst subunits in living cells has recently shown the complex to be much more dynamic than previously appreciated, and exposed how little we still know about its function and regulation.