JC papovavirus large tumor (T)-antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non-AIDS patients with progressive multifocal leukoencephalopathy.
JC papovavirus large tumor (T)-antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non-AIDS patients with progressive multifocal leukoencephalopathy.
复制标题
JC 乳多空病毒大肿瘤 (T) 抗原在获得性免疫缺陷综合征 (AIDS) 和患有进行性多灶性白质脑病的非艾滋病患者脑组织中的表达。
DOI：
10.1073/pnas.83.7.2271
复制
发表时间：
1986
影响因子：
11.1
通讯作者：
Webster,HD
中科院分区：
文献类型：
--
作者：
Stoner,GL;Ryschkewitsch,CF;Walker,DL;Webster,HD
进行性多灶性白质脑病 (PML) 是免疫功能低下患者中枢神经系统的 JC 乳多空病毒感染。众所周知，PML 中的脱髓鞘是由 JC 病毒感染少突神经胶质细胞引起的，但在受感染的人体组织中是否可以检测到非结构调节蛋白、大肿瘤 (T) 抗原尚不清楚。使用改进的过氧化物酶-抗过氧化物酶技术，我们发现在研究的 5 例 PML 病例中，病毒感染部位的细胞核中有 T 抗原表达，其中包括 2 例患有获得性免疫缺陷综合征 (AIDS) 的患者。艾滋病中 PML 的发生频率比其他免疫抑制性疾病高得多，并且 AIDS 中的 PML 可能代表中枢神经系统 JC 病毒感染的更严重形式。
Progressive multifocal leukoencephalopathy (PML) is a JC papovavirus infection of the central nervous system in immunocompromised patients. It is well established that demyelination in PML is caused by JC virus infection of oligodendroglia, but whether the nonstructural regulatory protein, large tumor (T) antigen, is detectable in infected human tissue was not known. Using a modification of the peroxidase-antiperoxidase technique, we found T antigen expressed in the nuclei of cells in virus-infected sites in five cases of PML studied, including two with acquired immune deficiency syndrome (AIDS). PML occurs in AIDS at a much higher frequency than in other immunosuppressive disorders, and PML in AIDS may represent a more severe form of JC virus infection of the central nervous system.