Mast cell biology: introduction and overview.

Mast cell biology: introduction and overview.
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DOI:
10.1007/978-1-4419-9533-9_1
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发表时间:
2011
影响因子:
--
通讯作者:
Metcalfe, Dean D.
Metcalfe, Dean D.
中科院分区:
医学4区
文献类型:
--
作者:
Gilfillan, Alasdair M.;Austin, Sarah J.;Metcalfe, Dean D.

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近年来,肥大细胞生物学的领域已经远远超出了历史上一直关注的特应性疾病和间质性松弛的界限。负责肥大细胞发育和调节的生化和信号事件已得到越来越多的研究,这在很大程度上得益于用于研究这些细胞的实验室技术的新突破。这些研究的结果是对肥大细胞的更全面的定义,包括对它们的整体生物学以及现在可以追溯到肥大细胞缺陷的各种疾病状态的更多见解。本介绍性章节概述并突出了肥大细胞生物学的各种主题,这些主题将在后续章节中进一步详细讨论。
In recent years, the field of mast cell biology has expanded well beyond the boundaries of atopic disorders and anaphy laxis, on which it has been historically focused. The biochemical and signaling events responsible for the development and regulation of mast cells has been increasingly studied, aided in large part by novel breakthroughs in laboratory techniques used to study these cells. The result of these studies has been a more comprehensive definition of mast cells that includes added insights to their overall biology as well as the various disease states that can now be traced to defects in mast cells. This introductory chapter outlines and highlights the various topics of mast cell biology that will be discussed in further detail in subsequent chapters.
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