Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima
Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima
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DOI：
10.1038/20601
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发表时间：
1999-05-27
期刊：
影响因子：
64.8
通讯作者：
Fraser, CM
中科院分区：
文献类型：
--
作者：
Nelson, KE;Clayton, RA;Fraser, CM
海栖热袍菌MSB8基因组全长1，860，725个碱基，包含1，877个预测的编码区，其中1，014个（54%）具有功能，863个（46%）功能未知。基因组分析揭示了许多参与糖和植物多糖降解的途径，以及108个仅在其他嗜热真细菌和嗜热假单胞菌基因组中具有直向同源物的基因。在迄今为止测序的真细菌中，T.海洋生物与古细菌基因最相似的基因比例最高（24%）。81个类似古细菌的基因聚集在T. maritima基因组的父系范围从4到20个酶。T. maritima和degenea在许多集群区域表明，横向基因转移可能发生在嗜热真细菌和degenea之间。
The 1,860,725-base-pair genome of Thermotoga maritima MSB8 contains 1,877 predicted coding regions, 1,014 (54%) of which have functional assignments and 863 (46%) of which are of unknown function. Genome analysis reveals numerous pathways involved in degradation of sugars and plant polysaccharides, and 108 genes that have orthologues only in the genomes of other thermophilic Eubacteria and Archaea. Of the Eubacteria sequenced to date, T. maritima has the highest percentage (24%) of genes that are most similar to archaeal genes. Eighty-one archaeal-like genes are clustered in 15 regions of the T. maritima genome that range in sire from 4 to 20 kilobases. Conservation of gene order between T. maritima and Archaea in many of the clustered regions suggests that lateral gene transfer may have occurred between thermophilic Eubacteria and Archaea.